The findings of a new study add to the increasing body of evidence linking side effects of the diabetes drugs Actos and Avandia to an increased risk of bone fractures.
According to new research published this month in the Journal of Clinical Endocrinology and Metabolism, older women taking Actos or Avandia were found to have a higher rate of bone fractures. Researchers found that the use of Avandia and Actos was far more common among women 50 and older who had suffered fractures than those who had not had bone fractures. They also found that the women taking the diabetes drugs were 50% more likely to have limited mobility.
Researchers found no link between the drugs and fractures in women under 50, suggesting that the effects seem to be limited to post-menopausal women. Among men, the drugs only seemed to increase the risk of fractures for those who were also taking a loop diuretic, like Lasix or Bumex.
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Learn MoreAvandia (rosiglitazone), manufactured by GlaxoSmithKline PLC, and Actos (pioglitazone), manufactured by Takeda Pharmaceuticals North America Inc., are both part of a class of medications known as thiazolidinedione agents, which are used to treat type 2 diabetes by helping control blood sugar levels.
The Avandia fracture problems are one of several safety concerns associated with GlaxoSmithKline’s drug, which many consumer advocates indicate should be removed from the market because of the health risks appear to outweight the benefits provided by the medication. Other side effects of Avandia could include an increased risk of heart attacks, congestive heart failure, liver failure and a type of vision loss known as macular edema.
The FDA added a “black box” warning in 2007 regarding the risk of heart attacks from Avandia, which some experts estimated could be responsible for as many as 100,000 heart attacks since the drug was first introduced. The FDA is currently considering whether to cancel clinical trials on Avandia heart problems, which some critics say would be unethical to continue.
GlaxoSmithKline has recently settled about 10,000 out of an estimated 13,000 Avandia lawsuits filed by former users of the drug who allege that the drug maker failed to adequately research their medication or warn users about the serious side effects.
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1 Comments
MR.T.L.C.January 30, 2011 at 4:43 pm
What I"M Typing about today Is what I have all ways typed about. That would be who is Responsible for THEIR Mistakes or Problems that needs to be FIXED. That would include just about all people on earth and where they Work. Right down to the air they breath. Where to start lets start with say the State I Live In. Here In W.Va. we have A State Road Division Their job is To Take care of fixing all [Show More]What I"M Typing about today Is what I have all ways typed about. That would be who is Responsible for THEIR Mistakes or Problems that needs to be FIXED. That would include just about all people on earth and where they Work. Right down to the air they breath. Where to start lets start with say the State I Live In. Here In W.Va. we have A State Road Division Their job is To Take care of fixing all the State Roads Here in W.Va. Enough Said. Now ALL Cities in W.Va. They do the Same as the state road division enough said. Except they have their own roads That need fixed and their problems to be solved ( THE STATES and Cities in each State.( Enough Said) Next get to the Main SUBJECT And Their Problems That Would Be ( PHARMACEUTICAL COMPANIES ) Why they have so many problems and mistakes That and The Public pays for It with Their Health or Even Their LIVES. Like I"VE all ways said The Pill Makers Makes Pills that Cure your depression or cure your heart or suppose to cure your diabetes. With side effects that can kill you or even Make one never be that same again HEATH Wise. The PHARMACEUTICAL COMPANIES Have got More problems than they can fix meaning how much does it cost them to give a drug to person just to fine out it can cause more harm then good to late they are dead or their health is gone for ever cant be fixed thanks to the pill makers. Ok say the pill maker gives his or her on pill their company made for their own child it caused the child to become more sicker than ever and more problems than ever before to their own child. Now they will know what it fills like when the pill that I gave my child they made from Their company can have real bad side effects. To make a long story short PHARMACEUTICAL Companies need to put black boxes on all Prescriptions why like I said cure your heart destroys your kidneys. Take a pill to give Your Penis an Erection What will happen you go BLIND or Lose Your HEARING. SOOOOOOOOOOO The Whole World is just one BIG Problem Right down to the Air WE breath. All the poisons going into the air we breath from factory next door. From The Company who makes ( C-8) WATER BEING POISONED FOR 61 YEARS. Just to name a few things that needs fixed and the problems solved or yet to be problems solved and fixed. It will cost a fortune but Their a Saying YOU CAN SPEND MILLIONS ON DOCTORS AND MEDICINE But STILL have Bad HEALTH. I"m just about done typing to you all. To SAY TO ALL WHO HAVE READ THIS/ THIS IS MY FIRST LETTER I"VE TYPED IN 2011 SO FAR. Will think of other things in the future to write about but the spirit has to hit me first,(pun) So to say I hope all who Haven"t Got Theirs yet gets their in this NEW YEAR 20011./That can be anything from lawsuits won to all your wishes come TRUE. I"M DONE??? From MR.T.L.C. - MAY GOD TAKE US ALL - THANK YOU