Alli Lawsuits

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Published: May 1st, 2010

The over-the-counter weight loss drug Alli, which contains orlistat, has been linked with reports of serious and potentially life-threatening liver damage.
In May 2010, the FDA required a new warning about the risk of Alli liver problems after identifying multiple reports of liver failure, liver transplant and death among users of orlistat-based medications.

ALLI LAWSUIT STATUS: Product liability lawyers are monitoring information about the risk of liver injury from orlistat to determine whether users who have experienced problems may be entitled to compensation through an Alli liver damage lawsuit.

MANUFACTURER: GlaxoSmithKline, PLC.

OVERVIEW: Alli (orlistat 60mg) is a lower dose, over-the-counter version of the prescription weight-loss drug Xenical (orlistat 120mg). It was approved by the FDA in 2007 for use in overweight adults in conjunction with a reduced calorie and low-fat diet. The drug works by preventing the absorption of fats, thereby reducing caloric intake.

Alli generated sales of $131 million during its first full year on the market. Known side effects of Alli include oily and loose stools, fecal incontinence, frequent or urgent bowel movements and flatulence, which tend to be most severe when the treatment is started and may decrease with time.

ALLI LIVER SIDE EFFECTS: In August 2009, the FDA issued an early communication indicating that they were reviewing the risk of liver problems associated with Alli side effects after receiving reports of liver injury associated with use of the drug.

On May 26, 2010, the FDA announced that it had found at least 13 cases of liver injury with orlistat worldwide, including at least one case of Alli liver problems in the United States. The reports involved cases of liver failure, liver transplant and death.

The most commonly reported side effects were a yellowing of the skin or whites of the eyes, known as jaundice, weakness and abdominal pain. The FDA has not determined that there is a definite association between liver injury and Xenical or other orlistat drugs, but users of Xenical should contact their health care professional if they experience symptoms of liver injury, including:

  • Weakness or fatigue
  • Fever
  • Jaundice
  • Brown Urine

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There Are 34 Comments So Far • (Add Your Comments)

  1. My brother and I had taken Alli for only a couple of months when it first came out on the market. Both of us are overweight and wanted to try it in conjunction with a healthy diet. When we both started having bowel incontinence and/or horribly painful bowel movements we stopped taking Alli thinking it would solve the problem, It’s now November of 2010 and we both still suffer from bouts of bowel incontinence and severe pain. It affects us in so many ways. It has made us late for work, caused embarrassment in public places, and ruined a lot of clothes. I would never suggest anyone taking this pill to lose weight it has changed mine and my brothers lives permanently for the worse.

  2. I too was a regular user of Alli. My use extended over a period of about a year and six months. Do not assume rectal-bleeding are hermorroids.
    After about 3 or 4 months, I was bleeding, continued taking it anyway.
    Come time to get a colonoscopy, the doctor found colon-rectal cancer.
    I stopped taking it after the scope immediately. Went to google Alli and a cancer study in mice determined colon-cancer in alli fed mice. So now, I got the picture and am waiting to see if the cancer mestatized to liver.
    Yea, had pre-chemo and radiation. Rectum removed and part of colon and 25 lympnodes, Get the picture!! No post chemo for me, Be sure to have a K-Ras test done before anyone proposes Chemo is you have colon-rectal cancer.

  3. I to used Alli for a couple of months and also had bowel movements and my self. About 4 months later i was diagnosed with severe ulcerative colitis and in july and aug i had two emergency surges to removal all of my large intestines. i lost so much blood i had to receive a total of 7 units of blood. i just want some answers and why is there not a lawsuit against them for colon/intestines damage. Im only 27 so what am i suppose to do now and about to lose the last 4 inches of my rectum.

  4. I am 32 years old and took ALLI for about 6 weeks. I was recently only taking 1 or 2 pills a day and I am having bloody bowel movements. I have an appointment to have it checked by my doctor. These posts have me scared…I feel sick! I reported my symptoms to GSK and they called me the next day. They know something is up. Why would they continue to make a drug that is killing people…I was healthy and just a little chunky before taking this drug and now I could have a serious health issue.

  5. I have taken alli in the past and started taking it again ,only to find out how bad it is for you. i was just told last week i have a fatty liver . i will never take this alli pill again . I took it to help me get healthy ,and know to find out i may have damaged my liver. This sickens me.

  6. took alli damaged my pancreas. had tail of pancreas and spleen removed, im always sick.

  7. I took alli for one year and became very ill and i am still on medication for damaged liver i still have very bad itching. I wish they would take it off the market so other people will not suffer the way i have. Prior to takin alli i was perfectly healthy-not obese and not taking any meds

  8. I took Alli when it first came out in 2007. I was not considered as obese. I just wanted to lose 10lbs. I was healthy with no bad habits such as smoking or drinking. After about a month I quit taking it because I did not like the side effects. Since then I have I had GI problems. I had to have my gallbladder removed. Now, I am still having problems. I have undergone many tests and have been diagnosed with chronic pancreatitis. I am 34-years-old and do not fit the description for someone who would have chronic pancreatitis! I do not drink and have no family history of pancreatic problems. Two days ago I found my receipt of when I purcahsed the Alli. I couldn’t believe it! I will be holding on to it as proof! I think Alli is responsible for my GI problems!

  9. I have only been taking Alli for a short time. Today, I woke up with a swollen neck, all the way from my chin to my collar bones. Has anyone else experienced this? Also, the entire surface area of my abdomen is sore to the touch. Has anyone else experienced this? Does anyone have any suggestions of what it could mean? I am stopping the Alli pill. I didn’t even know it was dangerous, my mother called me and begged me to stop it after doing a search about it on the web. I’m going to the doctor’s tomorrow just to be safe. I don’t know what else to do, my neck is so swollen.

  10. I took Alli several years ago for a few months. About a year later I found out I have a liver problem and was on steriods for over a year to control it. I now have diabeties & cholesterol problems that I never had before. They could not figure out what caused the liver problems. From what I have read I believe it was the Alli. I still have a bottle of it in my cabnet I will keep as proof. DO NOT USE ALLI IT IS Dangerous.

  11. WOW!! This is Amazing. I am a 35 yr old who was a healthy hyper always running about girl 2 1/2 years ago. I took Alli for about a month. I never thought anything about it. I developed chronic severe diarrhea and lost my rectum. It got deattached and fell out and again as of several days ago and has also made my vagina pushed out. Another surgery. Wow. This is Unbelievable. Please feel free to contact me at any time. This has completely changed my life.
    Thank you for sharing!! & I wish you the Very Best!!
    Kindest Regards,
    ~Jeannie

  12. i took alli when it first came out and then started it again in august of 2010 . in octomber of 2010 i ended up in the hospital and found uout that i had pancreatitis.

  13. Im a 27yo healthy but slightly heavey female who started alli 4 mos ago,2 mos into it & 30lbs gone I stopped alli and thats when my GI problems started, nausea,vomitting & diarrehia. My symptoms increased to the point where I couldnt work and ran up doctor bills doing upper endoscopy,ultrasound,hida scan,ct with contrast dye and multiple trips to ER. I just had gallbladder removed yesterday!! I hope this takes care of my problems and I learned my lesson, i was happy & healthy being fat! I really hope nobody else suffers like I did, I wish I found these postings before I took alli,its ruined my life,i’ll never be the same thats forsure,one organ less!!!

  14. I took Alli for about 3 months a few years ago. I never took more than recommended, actually less. Within 2 months I was in the hospital with severe constipation. I had my first colonostocpy at the age of 32, major GI issues. I was overall healthy prior to taking this drug, Cronic diarrehia, constipation, unable to tolerate most foods, hiatal hernia, GERD and severe pain is all I have now. I just had my gallbladder removed, never did I have issues prior to using this drug. I am still undergoing tests, scared of what is next.

  15. I started taking alli when it first came out and along with the alli I also changed my diet and went faithfully to the gym. It was successful, I lost 125 pounds. THen On Fathers Day 2009 I found myself in the ER with severe abdominal pain. After the Cat Scan I was diagnosed with Stage 4 Anal Cancer with Liver Metastasis. My initial oncologist told me my cancer was not curable and I had only 18 months to live. I was only 44, still had 2 children at home and was on my way to completing my Masters Degree. I went to another oncologist, had 2 years of very aggressive chemo. I am currently cancer free, but suffer many severe and permanent side effects from the chemo. My life has been destroyed and because of all the steroids i was on to be able to endure the chemo all my weight came back plus more. I now find much difficulty in walking because the chemo has destroyed my knee joints, I have severe neuropathy in both my hands and feet which my neurologist says is permanent, so now I cant cook, drive and it is very difficult to type. I cant believe the FDA and Alli’s makers didnt do their homework on this and allowed this drug to be sold and consumed by the unsuspecting general public. It almost took my life…and who knows it still might if this cancer decides to become active again….Watch out if you take alli…it is not safe and it definately isn;t worth your life.

  16. I took Alli in the summer of 2008 and took it until November 2008 . In i probably lost abou 55 lbs. January 2009 I started to regain some of the weight back so I started Alli again. I was surprised that I did not get the same results this time – I also did not have the “after effects” so I discontinued it shortly after restarting. In October 2009 I started to have severe pain in the lower abdomen . I was 44 and the doctors could not figure out what was wrong with me. I had my gall bladder removed in January 2010, but the pain persisted. On may 1, 2010 I went in for a colonoscopy. Two days before mother’s day I was diagnosed with cancer. Five days later I had a tumor the size of my fist removed with 75% of my colon. I then went through 6 months of chemo. Believe me IT IS NOT WORTH THE RISK

  17. I took Alli about 2 years ago. I lost weight however the crappy side effects that came with it are woth it. I knew instantly when I ate something that was to fatty. (DIAHREA) I had to know where the bathrooms everywhere I went. I have not taken Alli 2 years but I now have I still have diahrea 3times a week. Ihave ruined more clothes and underwera than this product is worth. I can’t go on long walks,shopping,or longtrips. I’m have to take anti- diahrea pills 3 times a week . My Dr. said the symtoms should have stopped when I stopped taking Alli. Maybe somebody needs to tell my body. Any one who is thinking about taking Alli should just learn to eat and excercise.

  18. I took Alli when it first came out for about two months. Didn’t like the side effects and stopped, Two years later, I was anemic. My doctor did a colonoscopy to be on the safe side…I had a baseball sized tumor in my colon. Colon cancer. It was removed (along with 12 inches of colon) and I went thru 6 months of chemo. I no longer can feel my feet and have trouble remembering and learning as a result of the chemo. I lost my job as my sales dropped. I am 42 years old with 2 children.

  19. I took alli for maybe 6 mths..Due to this im having severe constipation.Ive gained 30lbs. Now im so worried im having a colonoscopy n endoscopy..Reading everyones comments is scaring me..Please pray for me..

  20. I’ve taken Alli since it became an OTC drug. I’ve just had my spleen removed. It was enlarged and had a cluster of cysts. I cannot be sure, but I discontinued Alli. Maybe this is a side effect of Alli.

  21. I am a 31 year old male, I was recently diagnosed with diverticulitis and have terrible stomach pains as a result of taking Alli. Is there anything we can do to help ourselves ?

  22. I started taking alli a week ago and today Sunday Oct 7 2012 I started to bleed from my rectum I’m scared n I feel like I need to be in the toilet all day but only flesh n blood come out why help

  23. Took alli in small amounts for a few years. Now when I take it I have severe belching horrible stomach pain. It also caused me to have hemeroids. I think my gallbladder is having problems. I gave stomach pains when not taking alli now. This over the counter drug is dangerous in my opinion

  24. My heart goes out to all of you, but it’s kind of sad that people take these drugs without even knowing what they do or what the dangers are. Doing so, you’d find that these pharmacutical drugs are more dangerous and damaging to the body than most street drugs. If people just learned to love and accept themselves as they are, drug companies wouldn’t be able to attack people’s insecurities with these dangerous drugs.

    Wish you all the best and I’m truly sorry for what you’re going through. I hope it’s not forever.

  25. I’m posting again,as my problems have worsened. Don’t take this med!! I have severe digestive issues & pain n I can’t eat caused it’s messed up my stomach lining,bad….

  26. I am 39, 6 foot tall. healthy. not overweight. started Alli about 4 weeks ago. because of the side affects had to stop it today. I lost 6 pounds , from 191 to 185 but feel sorry I took the drug.

    all 4 weeks I have experiebced heart pain. FIRST time in my life. day and night. hopefully it will go away, was clean of this drug since this morning, and first time in 4 weeks have no heart pain

    also Alli made me very tired, depressed, gave me almost daily headaches. hortible diarrheas

  27. I came across this post after taking alli for two days..I went to the bathroom and I thought I started my peroid? I got really scared..I had blood, lots of bloodnin the toilet and toilet paper.The blood was coming from my rectum..I’m not taking th is drug again..if its this bad after two days amagine if was months…These post are scary and I’m saddened that so many are going through many issues…God bless

  28. I took Ali for about a year on and off. I started getting constipation, I never had irregular bowel movements, until after Ali. Constipation, stomache pains at 4am, neuropathy, this has affected me greatly. I can’t eat certain things or I become bloated, I cannot have a normal bowel movement on my own. This drug is lethal. I need to further my medical tests, but I’m nervous about the results.

  29. My mom took Alli and she got so scared because the whole time she was having blood just POUR out of her rectum every time she went to the bathroom. It didn\’t trickle, it wasn\’t a little bit. She said it was like urinating. This went on for weeks! She never made the connection until she went to the proctologist who told her to stop taking the Alli and -like that- the bleeding stopped. I hope nothing more serious is wrong inside that we haven\’t yet caught

  30. I started taking xenical when it was perscribed for me almost 10 yrs ago then went to alli. I am 71 yrs old and have no problems with it and have been taking it all these years.

  31. I love Alli. No ill effects, just weight loss, and sometimes I take a double dose. It’s great for those of us who have no problem with it. If you don’t like it,don’t take it. Sometimes I think we are turning into a nation of hypochondriacs!

  32. I suffered from kidney failure as a result of taking Alli off and on for many years.

  33. Gallbladder removed, hernia repair, G.I. problems , post colonoscopy with ulcerative leasions. Increased liver enzymes and hate it but due to abd. Pain I have have many MRI ‘S with & w/of contrast to rule out what maybe the cause. Only change was beginning alli. The cramps get so bad it’s undesirable. I read the reviews above. I will be having more specific testing done ASAP !

  34. I have taken Alli before, but just for a short time due to diarrhea and abdominal cramping. That was at least 3 or 4 years ago. About 3 weeks ago my husband and I started taking Alli. I stopped last night, and didn’t take it at all today. This morning and then this afternoon I continued having cramps and couldn’t seem to stay out of the bathroom. Later this afternoon, early evening, I had two more bowel movements. The second one is when I saw the bright red blood in my stool. I will not continue taking Alli (nor will my husband who has had frequent movements, but no blood at this point). We’re out of town right now, but as soon as we return, I will be seeing my doctor. I’ve never had blood in my stool before. Yes, I’ve lost weight already, but it’s not worth it!

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