The over-the-counter weight loss drug Alli, which contains orlistat, has been linked with reports of serious and potentially life-threatening liver damage.
In May 2010, the FDA required a new warning about the risk of Alli liver problems after identifying multiple reports of liver failure, liver transplant and death among users of orlistat-based medications.
ALLI LAWSUIT STATUS: Product liability lawyers are monitoring information about the risk of liver injury from orlistat to determine whether users who have experienced problems may be entitled to compensation through an Alli liver damage lawsuit.
MANUFACTURER: GlaxoSmithKline, PLC.
OVERVIEW: Alli (orlistat 60mg) is a lower dose, over-the-counter version of the prescription weight-loss drug Xenical (orlistat 120mg). It was approved by the FDA in 2007 for use in overweight adults in conjunction with a reduced calorie and low-fat diet. The drug works by preventing the absorption of fats, thereby reducing caloric intake.
Alli generated sales of $131 million during its first full year on the market. Known side effects of Alli include oily and loose stools, fecal incontinence, frequent or urgent bowel movements and flatulence, which tend to be most severe when the treatment is started and may decrease with time.
ALLI LIVER SIDE EFFECTS: In August 2009, the FDA issued an early communication indicating that they were reviewing the risk of liver problems associated with Alli side effects after receiving reports of liver injury associated with use of the drug.
On May 26, 2010, the FDA announced that it had found at least 13 cases of liver injury with orlistat worldwide, including at least one case of Alli liver problems in the United States. The reports involved cases of liver failure, liver transplant and death.
The most commonly reported side effects were a yellowing of the skin or whites of the eyes, known as jaundice, weakness and abdominal pain. The FDA has not determined that there is a definite association between liver injury and Xenical or other orlistat drugs, but users of Xenical should contact their health care professional if they experience symptoms of liver injury, including:
- Weakness or fatigue
- Brown Urine