Acetaminophen Pregnancy Side Effects May Impact Fetal Development, Scientists Warn
An international group of scientists warns that taking Tylenol or acetaminophen while pregnant may cause neurodevelopmental harm to the unborn child, raising further concerns about pregnancy side effects of the popular pain medication.
The warning is part of a consensus statement co-authored by 13 international scientists, which includes support from more than 91 other international scientists, and was published September 23, in the journal Nature Reviews Endocrinology.
The researchers are calling for the healthcare community to reconsider the safety of acetaminophen during pregnancy, highlighting risks associated with the active ingredient in Tylenol, which is commonly found in more than 600 different medications. Researchers warn that the medications should not be used among pregnant women until they are more thoroughly investigated for any potential impact on fetal development.
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Acetaminophen, also known as paracetamol in Europe, the U.K. and some other parts of the world, is widely used to relieve mild to moderate pain and is also often used as a fever reducer. It is also a common ingredient in cold and flu medications, which are frequently used by pregnant women. However, experimental and epidemiological research indicates exposure during pregnancy may affect fetal development and could increase the risks of some neurodevelopmental, reproductive and urogenital disorders, the researchers warn.
Although acetaminophen is approved by both the FDA and the European Medicines Agency, and both agencies consider it appropriate for use during pregnancy, the statement calls for precautionary action and for additional focused research on the use of acetaminophen use among pregnant women. Scientists from Australia, Brazil, Canada, Europe, Israel, Scotland, the UK and the US also call for increased awareness among doctors and other healthcare professionals when advising pregnant women on the use of Tylenol and other drugs containing acetaminophen.
In some cases, taking acetaminophen may be necessary. There are medical reasons to use the drug, including reducing fever and to treat severe pain. High fever is a known risk factor for fetal disorders, including neural tube defects and cardiovascular disorders.
However, most pregnant women are not using Tylenol to treat fever. Instead, the drug is commonly used to treat headache, back pain, muscle pain and inflammation. More than 50% of women worldwide use the drug during pregnancy. Most don’t believe acetaminophen can cause any side effects.
Acetaminophen is the only pain reliever generally considered safe for use during pregnancy, leaving pregnant women with few alternatives. Ibuprofen, the active ingredient in Advil or Motrin, has been linked with birth defects and damage to infant hearts.
At least one previous study has linked acetaminophen use during pregnancy to increased risk of attention deficit hyperactivity disorder (ADHD) and other neurodevelopmental problems. That study also called for the drug to be reevaluated for safety during pregnancy.
The consensus statement recommends pregnant women be warned at the beginning of pregnancy not to use Tylenol, unless its use is medically indicated, and to talk with their doctor if they are unsure whether to use the medication or not. When the drug is necessary, the researchers advised pregnant women to minimize their exposure and use the lowest effective dose for the shortest possible time.
TriciaMay 23, 2022 at 6:23 pm
My daughter is autistic. She was born with fluid on her brain causing permanent brain damage and she had epilepsy (absense epilepsy until she was 10). I took Tylenol on a regular during my pregnancy because I was told it was safe.
AudriannaMay 23, 2022 at 2:53 pm
My son has been diagnosed with oppositional Defiant Disorder, conduct disorder, ADHD, Autism, decreased IQ levels, and more. Tylenol was the only med for fever and pain relief you were allowed to take while pregnant back before he was born.
AliciaMay 20, 2022 at 2:54 pm
I have ADHD and I have 2 daughters that have it as well. My youngest is on the Autism spectrum and possibly my oldest as well.
AprilMay 19, 2022 at 10:16 pm
I have suffered migraines since I was a teenager, took tylonol through all 3 pregnancies, oldest daughter diagnosed adhd when she was 7 and I have long suspected she was on the autism spectrum. She is talking to her doctor about testing now that she is an adult. 2nd daughter diagnosed borderline adhd as a preteen, now an adult and youngest daughter shows signs of adhd but has not been formally tes[Show More]I have suffered migraines since I was a teenager, took tylonol through all 3 pregnancies, oldest daughter diagnosed adhd when she was 7 and I have long suspected she was on the autism spectrum. She is talking to her doctor about testing now that she is an adult. 2nd daughter diagnosed borderline adhd as a preteen, now an adult and youngest daughter shows signs of adhd but has not been formally tested.
DevondaMay 19, 2022 at 6:36 pm
My son has ADHD
ChelseyMay 18, 2022 at 5:03 pm
I took Tylenol my pregnant I think my daughter has signs of Autism and severe ADHD
JODIEMay 15, 2022 at 10:35 am
My son had struggled with learning disabilities his entire life. So has my daughter.
YadiraMay 12, 2022 at 4:40 pm
All three of my daughters have autism. I never understood why until reading this which makes sense since I did drink Tylenol during pregnancy.
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