Physical Fitness, Health Should be Factors in Antipsychotic Use: Experts

Health care providers should take a patient’s physical health and fitness into account when deciding whether to prescribe many popular antipsychotic medications, experts warned in a recently published medical journal article. 

The major cause of death for patients with severe mental illness is heart disease, often caused by weight gain and diabetes brought on, or exacerbated, by the use of antipsychotic drugs, according to the authors of an editorial in The Lancet medical journal. However, some of the side effects of antipsychotics could be mitigated if doctors and psychiatrists take a more overall look at the patient’s health and factor in diet, physical activity, smoking and other factors.

The use of antispychotics such as Seroquel, Zyprexa and Risperdal, have often been associated with weight gain and diabetes.

Did You Know?

AT&T Data Breach Impacts Millions of Customers

More than 73 million customers of AT&T may have had their names, addresses, phone numbers, Social Security numbers and other information released on the dark web due to a massive AT&T data breach. Lawsuits are being pursued to obtain financial compensation.

Learn More

A recent study in the Archives of General Psychiatry found that patients gained 11 to 13 pounds after taking Zyprexa for six to eight weeks. The patients also experienced increases in glucose, cholesterol, triglycerides, and in insulin levels when given a variety of atypical antipsychotics.

In light of these new findings and other studies, the editorial writers recommend that mental health care providers assess patients’ physical health when providing mental health care and medications, and take a more active role in patients’ health in conjunction with primary healthcare providers.

Atypical antipsychotics generate more than $12 billion in sales every year, with Seroquel leading the pack with nearly $4.45 billion in sales last year.

Last week it was reported that AstraZeneca has agreed to pay $350 million to settle Seroquel diabetes lawsuits, which involve claims filed by former users who allege that the drug maker failed to adequately warn about the risk of weight gain and diabetes.

As of December, the drug maker had paid $738 million in legal costs associated with Seroquel litigation. The company also paid an additional $520 million last year to settle criminal allegations by the U.S. Department of Justice (DOJ) that it illegally marketed Seroquel for off-label uses.

While doctors are free to prescribe approved medications for non-approved uses, drug makers are barred from promoting or encouraging such “off-label” use. Since it was approved, Seroquel has been used by more than 19 million people worldwide, and some people have estimated that at one time as much as 70% of all seroquel prescriptions were for unapproved uses.

0 Comments

Share Your Comments

I authorize the above comments be posted on this page*

Want your comments reviewed by a lawyer?

To have an attorney review your comments and contact you about a potential case, provide your contact information below. This will not be published.

NOTE: Providing information for review by an attorney does not form an attorney-client relationship.

This field is for validation purposes and should be left unchanged.

More Top Stories

Gardasil Vaccine Lawsuits Being Prepared For Early Test Trials in Federal MDL
Gardasil Vaccine Lawsuits Being Prepared For Early Test Trials in Federal MDL (Posted yesterday)

In advance of a a conference this week, lawyers report that progress is being made to prepare a group of federal Gardasil vaccine lawsuits for early test trials, to help gauge how juries may respond to certain evidence and testimony that will be repeated throughout the litigation.

Enfamil Lawsuit Claims Preemie Developed NEC After Being Fed Cow's Milk-Based Infant Formula
Enfamil Lawsuit Claims Preemie Developed NEC After Being Fed Cow's Milk-Based Infant Formula (Posted 2 days ago)

Cow's milk-based infant formula products are dangerous for premature infants, according to a mother's recent Enfamil lawsuit, filed after her newborn developed necrotizing enterocolitis and suffered through surgery and continuing negative health effects.

Ozempic MDL Lawsuits Reassigned To New Judge For Further Pretrial Proceedings
Ozempic MDL Lawsuits Reassigned To New Judge For Further Pretrial Proceedings (Posted 5 days ago)

All lawsuits over Ozempic, Mounjaro, Wegovy and other GLP-1 RA drugs to U.S. District Judge Karen S. Marston, following the death last month of the judge originally appointed to preside over all claims involving stomach paralysis and other gastrointestinal injuries.