Lantus Insulin Side Effects Linked to Risk of Cancer: Study

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New research suggests that side effects of Lantus, an artificial form of insulin manufactured by Sanofi-Aventis for diabetes, may increase the risk of developing cancer.

The report, published in the medical journal Diabetologia, found that in studies in Germany and Sweden, there was an increase in the incidence of cancer among diabetics using Lantus insulin. However, editors of the journal and the European Association for the Study of Diabetes (EASD) caution that the results are inconclusive and that more in-depth studies need to be done about the potential Lantus cancer risk.

Lantus (glargine) is an injection taken once per day, which slowly releases insulin into the blood over time. It has the second largest share of the diabetic drug treatment market and brought in $3.45 billion in worldwide sales last year. The drug was approved by FDA for diabetes treatment in 2000.

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The new report looked at data from an insurance database of 127,000 German insulin-users and found that diabetics taking low doses of Lantus over a year and a half had a 9% higher chance of developing cancer than people taking traditional human insulin treatments. When patients took higher doses of Lantus, the increased risk of being diagnosed with cancer jumped to 31% over those taking other insulin treatments.

After getting the results from the German data, researchers looked at databases in the U.K., Sweden and Scotland. The Swedish data showed a doubling of the risk of breast cancer, but the U.K. and Scotland studies showed no statistically significant increase connecting Lantus to cancer, prompting Diabetologia’s editors to urge caution at how the results of the studies are interpreted.

Professor Edwin Gale, editor of Diabetologia, and Professor Ulf Smith, president of EASD noted in an editorial accompanying the study that “the characteristics of the groups of patients taking Lantus insulin alone (generally older, higher blood pressure, more overweight) were different to those on other forms of insulin. Thus any difference in cancer risk could be attributed to the pre-treatment characteristics of the groups, rather than the treatment itself. Also, the numbers of cases of breast cancer in the Swedish and Scottish studies were very small, meaning the findings could have occurred due to chance.”

The EASD has said that the studies show an urgent need for more research into Lantus side effects. Smith and Gale say such research should come from more database analysis, as conducting clinical trials would be slow and unethical.

Sanofi officials have called the reports findings inconclusive, standing by the safety of their product. Lantus insulin sales represent about 10% of the company’s pharmaceutical revenue.

Experts stress that patients should not stop using insulin and should contact their doctors to discuss any concerns.


150 Comments


Maurice
I,ve been diabetic since 1992. About 3yrs ago my Dr. put me on lantus.I,ve noticed that 2 lumps appeared on my left arm,then one on my stomach,then 3 on my left leg. Oh yes when i ask my Dr about this he said Oh its nothing. But after reading these comments.i believe that the lantus is causing this.

agnes
since I’ve been on Lantus I have swollen feet, swollen and painful fingers that have burning pain. also scabs and sores on my head. headaches on my left side of my head. I gained weight. I am hypothyroid and have have always had weight problems.

Wood
Have been diagnosed as Diabetic Type II for 10 years. First Dr started me off on Pills then Pills and Lantus then he put me on Aspirin regimen, then he also added Lidopril.(sp) (hi blood pressure med) . <—- this Hi blood mediciene only lasted 1 week as I go Pancreatis Had Pancreatitis for 2 weeks had to have liquid diet for 3 weeks !!! Still Pancreas was inflammed. Then referred to GI Doctor . G I Doctor took over he order CatScan, Ultrasound, Stress Test etc. All the things the primary Dr should have done. Well it seem GI Dr says 1st Dr had me on too much medicine . He cut me back to No Pills , exercise (must Sweat every day) & 70-90 units of Lantus . Sugars are still in control & now with increased activity I am losing weight (age 56) Hope to drop weight to 200 lbs in 16 months. [BTW I changed Doctors from the first one.. My GI Dr said he would that was enough for me]

Rebecca
HI all, well I have been reading all of you comments tahnks it has been very interesting! I am type one Diabetic for 29 years and have been on Lantus since it came out, I also take humalog and humulin at meals and to cover high blood sugars! my problem is horrible headaches!! I can take 13 units but the minute I add more even 1 more unit I get them. this is also A problem with levemir I need more insulin but just can’t tolerate it.. Has anyone had this problem and what have you done about?

Tina
I have been on Lantus for thee and one half mos.I feel terrible..I have joint and shoulder pain and stiffness,,I have little pimples on my scalp that are filled with fluid is this a side effect…I have had perfect a1c levels but my Dr switvched me from humulin N to lantus because I had a few low numbers on the humulin N and thought I would not wake up in the morning if I had a low blood sugar..so guess what ? I have had a few low’s 70 and 80’s on lantus..and my blood sugars are higher now on lantus ..I am so confused because I never had over 200 and now I do in the morning and nite…how long does it take for your body to regulate to this? I am so tired and I believe it is becaUSE MY #’S ARE TO HIGH ALSO i HAVE(MY mOTHER) DIED OF BREAST CANCER WHEN SHE WAS 40 YRS.OLD

George
I have been taking Lantis about a month and have started breaking out in big bumps that itch and want go away. Was wondering if this could be a side effect?

Diane
I have been on Lantus for 5 months. I have never felt worse in my life. I have no quality of life now. Need to get off this poison. I wake up in pain and go to bed in pain! I feel as though I’ve been hit by a mack truck! Joint pain is so bad and now my co-ordination is off. Can’t sleep, even bought a new mattress. Lantus worked great in the beginning and now my life is hell, sugars are slowly climbing, severe headaches, mood swings, irritability, and muscle tremors to go with the pain. And now I have to worry about getting cancer while on this “wonder” drug. Weight gain was especially heartbreaking especially after having worked so hard to get the weight off. This stuff is poison to my body. I know not everyone suffers from all these side effects but I get tired of being treated like I’m crazy when I hear from other people taking Lantus that they don’t have all these side effects. Some of us do react with all the aforementioned side effects so please don’t write us off just because something works for you and not others. To those of us in pain, get off this poison! Find an alternative.

Renee
I have been taking Lantus for two months. My weight has increased over 10 pounds eating the same diet as before. I am tired from the moment I wake up until I go to sleep. I have developed a lump by my belly button, and the Doctor says it is all right. However, I feel queasy throughout the day and my concentration time is quite limited. I notice my blood sugar fluctuates and there really is no noticeable change from my last results, however I did notice complete fluctuation without changing my diet in any way, and I am depressed a lot of the time.

Rachel
I take care of a man, hes 69 he get the 20 units of lantus in the am,then I check his blood sugar threw out the day a total of 4 times til bedtime…and then if its over 150 at any time in those checks he gets the Novolin shot…its a long sustaining insulin…..he may get anywhere from 3 to 10 units of the novolin…..yes and I agree with the above commenter…the Tumeric is the Indian “red dot” peoples antibiotic…so food is medecine…in this country look around…you see men that look like they are 8 months pregnant…with that GUT…so change your diet,then get wiend off that or any drug…asta la bye bye

Noelle
Physician heal thy self…..my friend from India,cut someones insulin in half, by them eating her indian food…they use tumeric,and corriander,all of their herbs are very beneficial for health…also, its very important to get excercise…do not use any kind of white food stuff..sugar bread,etc..also diet and cokes are the worst,even for a healthy person, coca cola changes your DNA…look it up….eat like a cave man…fruits,veggies,small amount of meat, nuts and beans…you can do it…lots of water…good luck…

Christy T
A lot of consumers don’t know, but YOU can turn in your side effects to the FDA on your own. You can go to the FDA website, or call their number for side effects. DOCTORS rarely turn in side effects. We have the power to turn them in ourselves.

Andy
I’ve been on one shot of Lantus at night time, and three shots of Apidra for about a month now. I had to change over because I was on two injections a day of mixed Actrapid and Insulatard which, over the last 5 years, created life-threatening hypos for me. I’ve been Type 1 since I was 4, in 1971. The Apidra seems to be doing it’s job of quickly lowering sugar, but the Lantus just seems like a pile of shit so far, as it simply doesn’t seem to exert any blood sugar control whatsoever, no matter what the dose. Although I’m not experiencing any of the mentioned side-effects so far, the system was sold to me on the pretext that it was so Versatile and, The Control Would Improve and, the Hypos would disappear. Well in terms of versatility, I’m now carrying around more medical equipment than Dr McCoy. In terms of improved control, well that may be possible if you have the eyes and concentration of a hawk, prepared to do literally a dozen or more blood tests per day. My sugars have been very varied so far, and particularly high at night when I’m trying to rely on the Lantus to do something. And in terms of Hypos disappearing, yeah they have disappeared, BECAUSE MY SUGAR IS REPEATEDLY HIGH!!! One of the things that really gets me about this Apidra-Lantus system is the fact that you can really, literally, only eat if you’re prepared to do an injection. I feel like a fucking junkie if I just want to go and have a bacon sandwich in a cafe. I’ve raised all these issues with my diabetic nurse, yet she says regular meals without snacks are manageable by anyone. I think she was kind of mistaking me for a Robot or a Prisoner. Like everyone here, I’m stuck in Catch-22. The old system could have killed me. The new system could kill me over time. And the health officials I deal with generally think that the onus is on me to manage my condition like a military operation FOREVER. As Insulin has been well understood since the 1920’s, can’t someone just invent a truly versatile regime which actually fucking works, and results in us being able to just lead normal fucking lives without being focused on all this shit 24 hours a day??

TONIA
I have been on lantus for about 4 years and every time I take 50/60units at bedtime I have severe numbness in my arm and pain in my right shoulder I told the doctor he said sometime its the nerves I am not crazy something is wrong. mation you wish to be published on this page…

Ann
I have been on Lantus since about 2003, along with Novolog. I read about the possibility that it promotes cancer growth, and stopped using it last week, went back on NPH. I’m stunned at the symptoms that have stopped, that I never thought had anything to do with Lantus! Swelling of legs and feet Shoulder pain Joints pain Depression Weight gain Fatigue Loss of concentration Cancer I was diagnosed with uterine cancer a year after starting Lantus. Related? Don’t know. But I gained 40 pounds after starting Lantus, and all those other symptoms developed over the past 7 years. I didn’t know they were related to Lantus, but they have all been going away since I stopped the Lantus. I wake up with no joint pain, I have energy and interest in my life now, I no longer sit on the couch vaguely depressed, I can concentrate on work, my shoulders are no longer stiff! The edema is getting better, and I have lost 5 pounds already without any effort. I also kept increasing my doses of Lantus without effect — I started with 40 u, and was up to 90, and still found it hard to control my blood sugars (I was taking Novolog for meals). I have now gone back to NPH and Novolin Regular. The regular stays in my system longer, doesn’t disappear as fast as Novolog, so it controls my PP better. Going back on NPH, I am taking the same dose I was back before I was switched to Lantus — 30 in the am, 15 in the pm. So the high dose of Lantus that didn’t work has been replaced by half that much NPH, for much better control. I’m a happy camper now — just need to ask my doctor to switch my prescriptions. But NPH and Regular are also available OTC, and cheaper than those new analogue insulins. I had no idea Lantus was doing all this to me! I have a new lease on life!

Bithia
I cannot believe these symptoms and have not related them to the Lantus – I am absolutely dumbfounded. Pains in my arms and shoulders, severe nausea which I wake up with and does not go away until I eat something, increased appetite and weight gain and now after 3 months on the Lantus, my sugar is uncontrolled again. Please help us all – I am sure we have legitimate complaints

Phil
Started Lantus/Humilog combo in January. Shoulder pain yes. I was shocked to see others with that. Weight gain and bloating yes. That side effect is on the box. I drink Elations and organic apple cider vinegar that helps the shoulder and joint pain quite well. I am getting very itchy all over, especially around my neck, inner arms, and face. Scratching to the point that my skin is beet red. Doctor says its all unrelated. I stopped my insulin and it started to fade, twice. Came back once I started again, 3 times. Doctor still says it’s unrelated. Think I’ll get a new doctor.

Dawn
My daughter started on Lantus at the age of 18. Whilst it seems to control her diabetes ok there seem to be some severe changes that have occured to her since the start of Lantus. Weight gain, mood swings and irrational aggression, severe depressiom and finally , occasional epileptic like seizures upon awakening in the mornings. Neurosurgeans have diagnosed her as epileptic, but the severe personality and physical changes happened when she started Lantus..?? seems related to me!….looking for similar reactions on-line to take references to medical prefessionals!!!!

Linda
I noted a very obvious increase in hunger after starting Lantus and gaining about 7 lb. I stopped it. My weight went back down to my norm. Went to PCP, HgbA1c 10.1. Started the Lantus again. Hungry again, craving sugar, shoulder pain – both shoulders, lack of concentration and EXTREME FATIGUE. I do have slight bursitis in right shoulder but that is in addition to and different from the bilateral shoulder aching. The only different thing I have done is to start the Lantus again and these symptoms are synomous with re-instituting this drug. I just cannot live like this. There must be Quality of Life which I certainly do not have on the Lantus.

MICKI
My mother went to the hospital and they switched her from her diabetes medication to Lantis. She took 50 units in the morning.Her blood sugars wre out of control and in the high 300 constantly for 2 months. She got a urinary tract infection,shouldr pain and died within a week from Septsis.Her Doctor failed to adjust hr dos or her concerns.She was a Kaiser Patient and they absolutely did not give her any standard of care. Please make sure your Doctors follow up on dosing. i blame Kaiser for my mothers passing and her Primary care for not adjusting her dose. I took her in at last 4 times and sh begged him.

Barb
I started taking Lantus on 4/13/10 at 6units and now have increased to 13units.. About 4 weeks ago i developed a rash on my legs and arms. Went to dermotoligist and they said it was not a reaction to the lantus..He gave me a steriod cream and in 1 1/2 weeks the reash disappeared. Last night I went to a tanning bed and this morning the rash is back!!!!!! Has anyone had a problem with lantus and tanning beds or the sun? Im on lantus and humalog and they are not controlling my sugar very well.. Help

Martha
I am on 33 u of Lantus at night. My dosage has been increased rapidly and, perhaps coincidentally but I doubt it, I now have strong burning from the shot. Worse, I have severe rash on my chest which is especially bad at night: no relief, but I will skip my shots until this is solved.

Marvin
I have been a diabetic for about 15 yrs. recently I stopped Actos(45 mg) completely and increased Lantus to 130 mg/day. No problems.

Joan
I have been on Lantus for a little over a month. I love it. No problems. Occassionally I have some burning when injecting but it is not bad. My blood glucose levels have gone from 400 to less than 120 anytime of day. I have changed to low carb eating leading to a 34 lb weight loss in a little over a month. I am not hungry like I was before starting Lantus but I really feel that Lantus is only as good as what you put in your mouth.

clare
iv been diabetic for 13years and iv got a 8month old baby.im on lantus twice a day (morning and night) and i feel terrible.i struggle to control my blood sugars,i go to bed with it within normal range then first thing in the morning they are in the late 20’s then all day long i battle with my sugars to get them normal again.every day i do this and it getting me down.im also constantly hungery,putting weight on (im now heavier than i was when i was pregnant)can anyone suggest anything as im getting now where when i go to my gp

Molly
I have had diabetes (type 1) for over 45 years. My mother has had diabetes (type 1) for over 75 years (she just received a medal for it). We both take Lantus and Humalog to control our blood sugars. We have been taking Lantus ever since it came on the market. We are both doing extremely well, with no side effects.

Sharon
Having been on various insulins for more than 30 years … I’ve felt that some of my issues of complaints have been somehow connected with insulin. I have been having severe weakness in both shoulders and arms. Now I’m also having the same weakness in my hips. I am quite challenged with both arms and hips for any activity … and I mean challenged! For some reason, I have had the opinion that there has been some type of an allergic reaction to whatever insulin I was on at any given time. This thought has been disputed by my family physician. After reading some comments in regard to Lantus (which I’m back on again) … I feel that maybe I’m not alone with the crazy feelings that I have. I am now being tested for Myasthenia Gravis and have been diagnosed with Parkinson’s. I am truly wondering if the insulin regime for so many years has brought on these suspected and known conditions.

Rae
I started on 10 Units of Lantus in October, 2009. I have had to increase my Lantus to 30 units at night (because I had to start taking prednisone for an autoimmune problem) and also have experienced severe itching all over. I have not found any way to relieve it. It keeps me awake sometimes at night. Also have had pain in my left shoulder. Not too severe but definitely noticeable. Never associated it with Lantus until reading these comments.

Richard
I’ve been on Lantus since July 2009 and have had terrible itching all over my body. It drives me crazy at times. Has anyone else experienced this? I am also on Humalog and take a shot before each meal and that also causes terrible itching. They both seem to work in regards to keeping my blood sugar levels between 75 and 120 as long as I stick to a 45 carb diet per meal and 30 carb snack 3 times a day. The itching has to stop please help and share if anyone has the same side effect and has found an answer. Thank you!

Matt
I have taken Lantus 10 units per day at night. Shoulder pain has appeared, skin rash is now beginning to appear. i may be allergic to this product. I am not sure. I am going to see my doctor soon to discuss these issues.

Nannie
Started Lantus Oct. 2006 . Had urinary track infection until Feb.2010 3 Specialest could not find a reason . doctor changed insluin and infection cleared up in five days.Had togo on long term antibotics urination was painful. urine had a foul odor. began to have trouble urinating. DIFFERENT INSULIN BLESSED RELIEF

Karen
I was on Lantus for perhaps 1 1/2 years. The most important aspect of it was I felt great. This of course changed. I began waking up being unable to move and once woke up face down on the floor not knowing how I got there. After about an hour or two I was essentially fine except with very high blood sugars after these episodes but it did encourage me to go to the hospital and get checked out. The first night there the nurse found me unresponsive with very dangerously low blood sugars and my insulin was changed. Over the past 5 years anytime I hear of a diabetic especially a fairly new diabetic having serious problems I just ask “Are you on Lantus?” Unfortunately I have been right on too many occassions.

Gary
I do have shoulder pain taking 80-90 units of Lantus twice per day.

Tom
As a type -1 for almost 50 years I switched to Lantus as my long term med—in combination with Humolog at meals—soon after it was released and have had NO PROBLEMS with it for all these years. I find that it works extremely well AND I am running A1cs of 5.8 to 6.1 for at least 5 years. Of course, such control inevitably requires that SHORT ACTING INSULIN at meals and, franklly, those who think they can maintain decent glucose numbers on ONE shot of long acting insulin alone—while still eat a fairly normal diet—are usually fooling themselves. One important thing I learned was to to divide my Lantus dose, taking PART in the morning—8 units—to work through the day and a second dose—5 units—at dinner time to help through the night. The numbers will vary from person to person but the dose splitting “idea” is the key. The problems people have reported MAY be due to the Lantus OR the manner and location of injecting OR failure to follow dietary controls OR something in the indivdual’s system that is just not tolerating the drug. It slso may be an easy out to blame so many problems that might appear on just this one medication. Diabetes has never been a “snap your fingers and you’re in control” condition. It takes time and work…lots of work…but it can pay off in the long run.

Christine
I have been taking Lantus at nigh for the past 4 years. There is weight gain but been insulin dependent has several side efects…The question is how can you survive without insulin?

James
I was started on Latus, on December 13,2007. At first it was working fine for two weeks. Then it stopped. I told my doctor’ and all they could say was it was my fault. I was on it for 2 years when another doctor took me off and put me on Janumet. That worked for about 4 months. ow i am back on lantus and i am haveing horrible pain, in my arms, chillis i can ot get ride of, and it burns at my injection points. If you look and the box or een the paper work, it dose not list any of these side effects. I dont know what to do. My doctors keep tell ing me it is in my head ans that lantus is the only thing i can take. what will it take for them to see something is wrong. Do i need to be in the hospital for them to take abetter look. Is there ayone out there that can offer ay help.

DAWN
My mother was on lantus, one day she woke up and stop taking all her medicines, she no longer has diabetes, high cholestrol, no high blood pressure and no neuropathy. She had a miracle and will never take prescription medicine from any doctor. God Bless Her!

jessica
How do you join the clas action against Lantus – please let me know thank you

Mary
I am experiencing many of the side effects listed. I have SEVERE headaches, the worst with an insullin called 70/30. Also muscle spasms, extreme shoulder pain. What worries me the most now is this link to cancer. It’s tough enough to have diabetes and all the side effects, but please I don’t want to go for chemo on top of everything.

rodger
i have been a diabetic since 1992′ i have been on orall medication up till 2006 the medicine i take is actos -glyburidemetforum’ well it quit working so my doctor added lantis plus my oral meds.i have been taking this medicine since2006 ‘i take 20 units a day and it still does not keep my blood really good’ so the doctor want’s to keep increasing the lantis i have done come to this conclusion if diabetes dosen’t get me the medicine will’think about it if they found a pill that would cure you the pharmecitical s would loose a lot of money.

nancy
I have been taking the Lantus, once daily, just 22 units, for about three months now. It is interesting as I have such pain in my shoulders too, and at night it gets much worse. I have found if I take a magnet to each shoulder at night, it helps tremendously with the pain. If you get the magnet in the wrong place, it will cause more pain – just move it around until you can feel relief. I didn’t even think about the Lantus till reading these comments.

clementine
I am in my first month of lantus, 30 units at bedtime. started after been hospitalized for Sacardosis and being on steriods for 7 days. The lantus was unsed in hospital to control steriod elevated blood sugar. But was sent home on it with 1000mg of metformin twice daily with GlipiZide 10mg daily. But now I am constantly craving sweets, excessive weight gain and uncontrolled hunger as well as a blood sugar of 379 lowest one in seven days was 189. My upper shoulder behind left lung are has been hurting non-stop since i got started on lantus. the pain feels like its tearing right through my heart like muscles and nerves fighting eachother. the pain is nearly unbearable. Could this be my lantus?

Carrie
I have been taking lantus about 10 months .Shortly after starting I developed very bad bilateral shoulder pains which get worse at night.Like throbbing toothaches. I can hardly lift my arms they feel tired.I stopped taking the lantus about a week ago and the night shoulder pains are better.,but my arms are still weak.I want to know if anyone else has had this experience.?Also I have gaind an uncomfortable amount of weight especislly around the midsection.

Donna
I have been a diebetic for 15 years and tried Byetta but made me very sick and now they have put me on Lantus for two weeks and have BAD headaches… and notices a weight gain and swelling in fingers and feet? anyone have any answers

Suzanne
HELP im so scared,i am taking Lantus 1 shot a day it has been working pretty well,but i get headaches.now they want to change me to pills and byetta and i hear that ia so bad also….

June
I have been switched from oral medication for Diabetes II SINCE mAY 2009 I AM 71 YRS OF AGE NORMALLY VERY ACTIVE AND WEIGH 54 kgs iNITIALLY THERE APPEARED TO BE GLUCOSE CONTROL BUT NOW IT IS NOT HAVING MUCH EFFECT. i AM INJECTING IN THE MORNING 20 UNITS BUT AM USUALLY STARTING THE DAY WITH AN ELEVATED GLUCOSE LEVEL OF 1.89PLUS BEFORE I HAVE EATEN ANY BREAKFAST.I AM INCREASINGLY TIRED AND WITH A MARKED LACK OF CONCENTRATION AND MEMORY RECALL. I have increased in weight SINCE MAY BY SOME 4 KGS. I WATCH MY DIET BUT I FEEL THE DIABETES IS TAKING CONTROL AND PROGRESSING RAPIDLY.

shahid
I Have Been Switched Since 8 Months To Lantus Insulin, But Now I feel It Work 12 Hours & Increase Blood Sugar Again.

Laura
Started on Lantus approx in 2000. I now have breast cancer

DR.Nabil Abdelhamid
more than 5years ago..i was prescribing Lantus insulin to my patients..their blood sugar well controlled..no side effect.no hypoglycemic episodes…..all patients tolerate Lantus.

Omar
I have been taking Lantus Insulin for the past 4 years and I have not come accross any side effects. We would like Sanofi-Aventis to research more about the results from Germany and Sweden to ensure our safety.

dave
i was on lantus for only one week and i have had lumps that are growing for the lst 6 months…doctors just lie and say its nothing,bullshit

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