Side Effects of Proscar, Avodart May Delay Prostate Cancer Diagnosis: Study

A new study suggest that use of Propecia, Proscar or Avodart, which are all used to treat enlarged prostates, could delay the diagnosis of prostate cancer, decreasing a patient’s risk of survival.

Researchers from the University of California San Diego published the findings in JAMA Internal Medicine on May 6, warning about the unintended side effects of a class of medications known as 5 α-reductase inhibitors (5-ARIs), which could suppress antigens that prostate cancer screenings rely on for diagnosis.

The population-based cohort study involved 80,875 men with prostate cancer, using data from the Veterans Affairs Informatics and Computing Infrastructure from January 1, 2001, to December 31, 2015. Researchers conducted follow up until December 31, 2017 or the patient’s death.

Did You Know?

AT&T Data Breach Impacts Millions of Customers

More than 73 million customers of AT&T may have had their names, addresses, phone numbers, Social Security numbers and other information released on the dark web due to a massive AT&T data breach. Lawsuits are being pursued to obtain financial compensation.

Learn More

The researchers noted that side effects of Proscar, Propecia and Avodart decreased serum prostate-specific antigen (PSA) concentrations by 50%. According to the findings, the median time for prostate cancer diagnosis from the first time elevated PSA levels were detected was 3.6 years for those taking the prostate drugs, compared to 1.4 years before diagnosis for those not taking the drugs.

Patients treated with the drugs and later given a prostate cancer diagnosis were more than twice as likely to have the disease go metastatic (spread to other organs) than those who did not take Proscar and Avodart, according to the findings.

“Results of this study demonstrate that prediagnostic use of 5-ARIs was associated with delayed diagnosis and worse cancer-specific outcomes in men with prostate cancer,” the researchers concluded. “These data highlight a continued need to raise awareness of 5-ARI-induced PSA suppression, establish clear guidelines for early prostate cancer detection, and motivate systems-based practices to facilitate optimal care for men who use 5-ARIs.”

Propecia Health Concerns

Propecia (finasteride) is a prescription medication marketed by Merck to help men restore natural hair loss that occurs with male pattern baldness. The drug was originally developed as an enlarged prostate treatment and marketed as Proscar in 1992. It was later approved to treat male pattern baldness, and was marketed under the name Propecia.

Both Proscar and Avodart are specifically made for the treatment of enlarged prostates. All three drugs have been linked to permanent sexual complications, such as erectile dysfunction, decreased libido, genital shrinkage and problems with cognition.

Several years ago, a number of Propecia lawsuits were filed by plaintiffs who said Merck has failed to adequately warn consumers or the medical community about the link between Propecia and sexual dysfunction, which may continue long after the medication is no longer used.

Prior warning information provided by the drug maker suggested that sexual dysfunction associated with the medication was rare, and that the problems resolve after use of the medication is discontinued.

Even after many men reported experiencing permanent sexual issues after Propecia use, Merck continued to provide information suggesting that the problems were temporary until the Propecia warning label was updated in April 2012.

0 Comments

Share Your Comments

I authorize the above comments be posted on this page*

Want your comments reviewed by a lawyer?

To have an attorney review your comments and contact you about a potential case, provide your contact information below. This will not be published.

NOTE: Providing information for review by an attorney does not form an attorney-client relationship.

This field is for validation purposes and should be left unchanged.

More Top Stories

AT&T Data Breach Class Action Claims Telecom Giant
AT&T Data Breach Class Action Claims Telecom Giant "Disregarded" Customer Financial Safety (Posted today)

A Missouri woman is one of the latest person to file an class action claim over the AT&T data breach, after the telecom company admitted that hackers stole millions of customers' personal information and sold it on the internet.

Plaintiffs Oppose Phased Discovery Over Suboxone Tooth Decay Risks in MDL
Plaintiffs Oppose Phased Discovery Over Suboxone Tooth Decay Risks in MDL (Posted yesterday)

Plaintiffs say a federal judge should not waste time on a phased discovery plan requiring them to first prove Suboxone strips can cause tooth decay, saying the science is obvious and such a plan could delay resolution of hundreds of product liability lawsuits.