Elavil, Topamax Side Effects Outweigh Benefits For Treating Child Migraines: Study

New research suggests that the side effects of Topamax and Elavil may make the drugs too dangerous for use in treating children with migraines. 

In a study published in the New England Journal of Medicine on January 12, researchers with the Cincinnati Children’s Hospital Medical Center compared the effectiveness of the anti-seizure medication Topamax (topiramate), the antidepressant Elavil (amitriptyline), and a placebo for children suffering from migraine headaches.

According to the findings, the potential risks associated with the medications outweigh the benefits, as the prescription treatments did not appear to be any more effective than the placebo.

Learn More About

Topamax Lawsuits

Side effects of Topamax during pregnancy linked to birth defect risk.

Learn More About this Lawsuit SEE IF YOU QUALIFY FOR COMPENSATION

The study involved a randomized, double-blinded, placebo-controlled trial where 361 youths between the ages of 8 and 17 were given either 2 mg per day of Topamax, 1 mg per kilogram per body weight per day of Elavil or a generic equivalent, or a placebo. Researchers looked for a relative reduction of 50% or more in the number of headache days the children suffered over a 24-week period, comparing it to the number suffered by the children over a 28-day period before they began taking the medications or the placebo.

The study found that there were no significant differences in the rates of migraines suffered by children in the three groups. However, children who received the actual drugs had a higher rate of adverse events.

Those given Elavil suffered higher rates of fatigue and dry mouth, and those given Topamax suffered from weight loss and paresthesia; which can be a sign of peripheral nerve damage and causes a “pins and needles” sensation.

In addition, the researchers reported that there was one suicide attempt in the Topamax group, and three cases of seriously altered moods in children given Elavil.

“There were no significant differences in reduction in headache frequency or headache-related disability in childhood and adolescent migraine with amitriptyline, topiramate, or placebo over a period of 24 weeks,” the researchers concluded. “The active drugs were associated with higher rates of adverse events.”

1 Comments

  • BryannaMarch 27, 2021 at 3:41 am

    I was prescribed this medication as a young teenager by my pediatrician. Didn't help with my migraines but definitely altered my mental state

Share Your Comments

I authorize the above comments be posted on this page*

Want your comments reviewed by a lawyer?

To have an attorney review your comments and contact you about a potential case, provide your contact information below. This will not be published.

NOTE: Providing information for review by an attorney does not form an attorney-client relationship.

This field is for validation purposes and should be left unchanged.

More Top Stories

Management of Ozempic Lawsuit Pretrial Proceedings To Be Reassigned Following Death of MDL Judge
Management of Ozempic Lawsuit Pretrial Proceedings To Be Reassigned Following Death of MDL Judge (Posted today)

The judge overseeing Ozempic lawsuits consolidated in federal court has died, requiring a new judge to be assigned to oversee coordinated pretrial proceedings over claims the diabetes drug and similar medications caused stomach paralysis and other intestinal complications.

Baby Food Injury Lawyers Appointed To Leadership Roles in Autism, ADHD Lawsuits Over Heavy Metal Contamination
Baby Food Injury Lawyers Appointed To Leadership Roles in Autism, ADHD Lawsuits Over Heavy Metal Contamination (Posted 2 days ago)

A group of 19 plaintiffs' lawyers have been appointed to serve in various leadership position during the consolidated pretrial proceedings for all baby food injury lawsuits, taking actions that benefit all families pursuing claims for children diagnosed with autism, ADHD or other developmental problems from toxic heavy metals found in many popular products sold in recent years.