Rhabdomyolysis Warning Added to Adderall, Other ADHD Drugs

  • Written by: Irvin Jackson

Federal drug regulators have announced that new warnings will be added to Attention Deficit and Hyperactivity Disorder (ADHD) medications, such as Adderall, Concerta, Daytrana and Ritalin, indicating that the drugs may cause a severe form of muscle injury and kidney damage, known as rhabdomyolysis.

On May 13, the FDA Center for Drug Evaluation and Research approved safety labeling changes for ADHD drugs, to add rhabdomyolysis to the list of possible adverse reactions that may be caused by amphetamine-based medications. The warning comes as the drugs continue to be prescribed to children at increased rates.

Rhabdomyolysis is a side effect associated with several different types of medications, which causes muscle fibers to begin to break down, releasing a protein called myoglobin, which can damage the kidneys as they attempt to filter it out of the bloodstream.

Symptoms of rhabdomyolysis include muscle cramps, tenderness, stiffness, pain or spasms. The illness is usually reported in patients over 65 years of age or those who have renal impairment or uncontrolled hypothyroidism, however these drugs are prescribed heavily to children and young adults. Over time, rhabdomyolysis can lead to kidney damage and even kidney failure. Some may require dialysis or a kidney transplant.

The list of drugs that must now carry the rhabdomyolysis warning includes Adderall, Adderall XR, Concerta, Daytana, Desoxyn, Dexedrine, Focalin, Focalin XR, metadate CD, Methylin, Quillivant XR, Ritalin, Ritalin LA, Ritalin SR, Strattera and Vyvanse.

Concerns About ADHD Drug Overuse

The new FDA label warnings comes amid increasing concerns over the perceived overprescribing of ADHD drugs and their potential health risks.

In April, the U.S. Centers for Disease Control and Prevention (CDC) released the first national study on the treatment of ADHD in children. The CDC found that 40% of children diagnosed with ADHD were being treated with medication, compared to only 10% receiving therapy alone and only 30% receiving a combination of therapy and drug treatment. About 10% received no treatment at all while another 10% were treated with dietary supplements alone.

Another study, published in July 2014 by Danish researchers, found that children taking Ritalin, Dexedrine, Concerta and other amphetamines for ADHD showed increased rates of hypertension, heart disease, and arrhythmias, among other heart problems. Their findings indicated a dose-specific response between ADHD drug use and cardiovascular problems.

About 15% of all high school-age children in the United States have been diagnosed with ADHD, but some experts say that number should be closer to 5%.

One early advocate of stimulate treatment for children with ADHD, Dr. Keith Conners of Duke University, said that the rate of children now being diagnosed with ADHD and placed on drug treatments is “preposterous” and called ADHD an epidemic manufactured by drug companies.

Conners and others say that the inflated diagnoses and prescriptions are the result of a 20 year effort by the pharmaceutical industry to cash in on concerned parents hoping that poor grades and typical childhood behavior can be cured with drugs.

While some manufacturers paid off doctors to speak on their drugs behalf, others have gone as far as releasing comic books encouraging children to take medication to address ADHD. At some point since 2000, Conners noted that the FDA has cited every major ADHD drug manufacturer for false and misleading advertising about their ADHD drugs.

Those efforts led to $9 billion in sales for the ADHD drug industry in 2012, and 3.5 million children using ADHD medications.

Tags: , , , , , ,


  1. Janet Reply

    I’m 55 and have been on Adderal or Ritalin for several years. I was hospitalized for 4 days with Rhabdo after completing some very light workouts. Now I’m told that I have to be extra careful, and minimize strength training. I still don’t feel well, dizzy and extremely weak. Does this risk fade with time? I want my weight training back!

  2. JIm Reply

    Stop taking dangerous drugs like Adderal! Don’t be a junkie..

  3. Deb Reply

    I just found out I have third stage chronic kidney disease these drugs have been prescribed to me for years

  4. Virginia Reply

    Our son, 29, is on Adderall for depression (he has never been formally diagnosed with ADHD) by his psychiatrist. He has developed protein in his urine and has a Creatinine of 1.7. He also takes Vyvanse and other meds prescribed by this Dr. I am in fear for his health. As his mom and myself a kidney transplant survivor. I am painfully aware of the dire ramifications of kidney failure. He is aware but does not want/refuses to stop taking this drug. Is the Dr. correct to keep him on this amphetamine for depression?

  5. Bert Reply

    I take Adderall for adhd, and I found that it works really well for depression that is associated with Adhd. Adhd is caused by a Dopamine deficiency, Dopamine is 1 of 3 hormones your brain makes for reward and pleasure. When you take Adderall you need to drink plenty of water.

  6. Carol Reply

    Was prescribed adderall for 12 years and went off 7 months ago after reading how bad it is for you but unfortunately I have serious wounds on my legs from itchiness and realize my condition is most likely from years of taking this dangerous drug. Why did my doctor (pharmacologist/ psychiatrist keep me on this medication for So long?! Surely he must have known the dangers! I was treated twice for Cellulitus 3 years ago in the ER and now think it was to do with adderall, legs had swelled up so bad I could hardly walk! Scared to death now because I’m having symptoms of kidney problems! Adderall is a toxic drug! Wish I never took it!

  7. Jane Reply

    So my name is Jane and I wanted to get some answers. I have been on Adderall for over 7 years. I recently had some side affects. I thought I had diverticulitis and they sent me to see the GI Doctor and they took MRI and the results were no diverticulitis but I had renal cyst and my doctor said I was fine. I started crying because I know I wasn’t fine. My psychiatrist put me on a higher does. I recently moved back by my parents but since I got the results. I had symptoms such as swelling in my feet, ankles and leg. My feet would turn purple and my hands. My skin was dry. I went to my family doctor to get a second opinion for my results. So he dropped a blood test and he called me and told me my kidney were running slow and needed a ultrasound sound. Anyone experience scratching of the sculp and I have lesions and painful sore on my sculp, face and back and shoulders? Anyone had Acute renal failure? Kidney cysit ?

  8. Alison Reply

    I was on both medications Ritalin and Concerta I had many muscle pains, tachycardia, shortness of breath, and muscle spasms in my scalp at 14 I was diagnosed with stage 1 kidney disease (FSGS) I’m saddened and frustrated to read all your comments and I’m sorry you have these health problems now, I truly hope children these days are not among the victims of these medicines.

  • Share Your Comments

  • Have Your Comments Reviewed by a Lawyer

    Provide additional contact information if you want an attorney to review your comments and contact you about a potential case. This information will not be published.
  • NOTE: Providing information for review by an attorney does not form an attorney-client relationship.

  • This field is for validation purposes and should be left unchanged.
Contact A Lawyer

Contact A Lawyer

Have A Potential Case Reviewed By An Attorney

  • This field is for validation purposes and should be left unchanged.