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Invisalign Invisible Braces Linked to Reports of Serious Allergic Reactions December 8, 2010 Staff Writers Add Your Comments Federal investigators have issued a warning to the makers of Invisalign for a failure to notify the FDA about potential problems with their invisible braces, which have reportedly caused some users to suffer extreme allergic reactions. The FDA Invisalign “invisible braces” warning letter was issued last month and accuses Align Technology, Inc. of failing to pass on adverse event reports to the agency in a timely manner. Some of the complaints, which include incidents of severe allergic reactions that have required hospitalization in some cases, date back to November 2007, but were not reported to the FDA as required by law. According to the warning letter, allergic reactions to Invisalign braces reported by users include swollen and irritated lips, sore throats, a burning sensation on the tongue, ulcerations in the mouth and swollen lymph nodes. In some instances Invisalign side effects led consumers to stop using the braces. Do You Know about… hair dye cancer lawsuits For Salon Professionals Hair dye lawsuits are being pursued for salon professionals who were routinely exposed to hair dye chemicals and diagnosed with bladder cancer or breast cancer. See if you qualify for a hair dye cancer lawsuit settlement. Learn More SEE IF YOU QUALIFY FOR COMPENSATION Do You Know About… hair dye cancer lawsuits For Salon Professionals Hair dye lawsuits are being pursued for salon professionals who were routinely exposed to hair dye chemicals and diagnosed with bladder cancer or breast cancer. See if you qualify for a hair dye cancer lawsuit settlement. Learn More SEE IF YOU QUALIFY FOR COMPENSATION Federal regulations require medical device and drug companies who receive consumer complaints regarding potential side effects of their products to forward those adverse event reports on to FDA within 30 calendar days of receiving them or otherwise becoming aware of the incident. In a response to the letter, Align Technology said in a press release that it was attempting to fully comply with the FDA’s concerns, that they are turning over all copies of documentation requested by the agency and that they want to resolve the issue “with minimal impact on the company.” Align Technology claims that the Invisalign system has been used by more than 1.3 million people since it received FDA approval in 1998. The product line includes Invisalign, Invisalign Teen, Invisalign Assist, Invisalign Express and Vivera Retainers. It was not clear from the warning letter which Invisalign products were associated with the reported problems and which were not. Tags: Allergic Reaction, Invisalign, Medical Device More Lawsuit Stories Ozempic Side Effects Caused Stomach Paralysis and Severe Abdominal Pain, Lawsuit Claims April 18, 2025 Zyn Nicotine Pouches Lawsuit Alleges Tobacco Product Is Marketed to Minors April 18, 2025 Radiation from CT Scans Given in 2023 Alone May Cause More Than 100,000 Future Cancer Cases: Study April 18, 2025 176 Comments Alison May 28, 2024 I shared my son’s story on June 2, 2023 of his first and second ever seizures after starting Invisalign. I’m here to update that it has been 14 months since his last seizure and he just had his second EEG. The EEG came back normal! He no longer has epilepsy. The Invisalign hasn’t been in his mouth since March 29, 2023. We are more sure now that they caused his seizures. Pete May 16, 2024 I have all of the most common complaints: Fatigue, swollen face, sore throat and glands, lost teeth, anxiety, headache. I haven’t been able to figure out the cause. I’ve been feeling this way for 8 years since beginning Invisalign. I asked my dentist and he assured that everything was safe. Since reading these comments it seems my symptoms are connected to wearing Invisalign Laurence January 14, 2024 I began my Invisalign treatment in 2021 with the promise of correcting my anterior open bite. The assurance was a definitive “100% resolution”… yet here I am, £4,200 lighter and burdened with a condition I didn’t bargain for – TMD. My confidence in the promised solution has been replaced by constant discomfort, a tension in my jaw that seems to be an unwelcome side effect of wearing aligners for the advised 20 to 22 hours a day. My efforts to adapt to the presence of the plastic resulted in excessive jaw clenching, and my calls for help seem to echo into a void of indifference. Despite numerous attempts to seek support from medical professionals and Align Technology, my concerns seem to be met with an unsettling silence. And the most shocking part? The UK consumer care team, whose response — or lack thereof — paints a clear picture: once the payment is processed and the treatment is supposedly ‘finished’ , the patient’s experience no longer seems to merit attention. This isn’t just about misaligned teeth anymore… it’s about my well-being. My quality of life and mental health have taken a backseat in the eyes of those who I hoped would guide me through to a resolution. Such an ordeal cannot be swept under the rug. There must be accountability! Laurence January 13, 2024 I began my Invisalign journey in 2021, forking out £4,200 in the hope of fixing my anterior open bite. I was promised that it would “100% resolve the problem”… I was left sorely disappointed. Instead, I now struggle with TMD and other health issues I never had before the treatment. I’m convinced that the constant use of these aligners caused this issue, as I had to wear them for 20 to 22 hours daily. My jaw felt constantly tense, requiring me to clench it in discomfort to accommodate the plastic in my mouth. Despite seeking help from various medical experts and Align Technology, my concerns and complaints have been brushed aside altogether. The UK ‘consumer care’ team is a complete letdown — they don’t seem to care once they’ve pocketed your money. This entire ordeal has deeply affected my quality of life and mental well-being… And I will not settle until I get justice! ELysia January 7, 2024 It has taken me years… since April 2020 until now and I still have six trays to go… to be done my treatments. This is for numerous reasons… as my original trays never fit properly and caused lots of cuts in my mouth. Eventually they agreed to make me new trays. However, once I could finally manage to wear them reguarly, I kept getting sick. I noticed it was causing me to have a sore throat and be more prone to getting sick. Whenever I stopped for a few days, my throat recovered. I now have to take out the tray after using it at night and oil pull for fifteen minutes. This is improving the throat and preventing it from getting sore. I do however, have a rash above my upper lip and on the sides. This too, starts to go away when I stop using the trays but then reappears when I am trying to be consistent with the trays. As someone who once had braces back in middle school, I would say that braces were a breeze compared to this. I thought I’d look today to see if there was harm in the plastics again and low and behold there can be. At this point, I’m hoping to suck it up until treatment is done because they are realigning my teeth which my dentist said I needed to have a healthy bite. It’s certainly not been easy but I hope to perservere and be done asap. Rafael August 3, 2023 I’ve been having a lot of health problems. Dry mouth, sore throat, tonsil stones, shortness of breath, insomnia, blurry vision. I have a hormone Imbalance, my back hurts on the very top part ( feels like my Adrenal area. Very tight chest like something is sitting in my chest. All of this started when I got invisilign. I noticed that when I wear the retainer at night. My back pain starts all over. In the day time when I don’t use them, I feel less pain. I will not wear them to see what happens. Reading all of this, connects the plastic to all my symptoms. I want my health back. No one talks about this. It’s insane and scary that we have to look for answers on our own. Living in the best country in the world and having the technology. I guess our health is not important. E Dayton OH July 1, 2023 It took me several weeks before I realized what was going on. I was 49ish two years ago when I started my invisalign journey. About the third week into it, my tongue started tingling. The next week my throat tingled. Then it started to burn. The next week it was burning my esophagus. The next week it was burning my belly and my eyes. My lips were somewhat swollen. My face was a bit pinker than normal. I suspected it was the invisalign but I had already put $1000 deposit down and really didn’t want to stop. By the 6th week, I was waking up in the middle of the night because it was so painful. I had to stop. My orthodontist said he’d never heard of any problems but he didn’t charge extra for me to start over with metal braces and didn’t have any problems with them. I just got my braces off about two months ago. I do have to wear plastic retainers 24 hours a day for 3 months. I’m watching for signs this time. I do have to say, I feel cold rather than burning. in my esophagus and roof of mouth but it could be because of GERD at my age. After 3 months, I only have to wear them at night. I can ask to switch to Hawley but it wasn’t recommended. Karen June 19, 2023 After 2 days wearing Invisalign aligners, I lost my tastebuds. Everything tasted TERRIBLE. Eating became a problem. I lost 10+ lbs which may sound great BUT it was NOT. My orthodontist sent me to an Oral Medical Specialist 45 minutes away for treatment. I had to fill & mix prescriptions, then “rinse and swish for 3 mins, 4 times a day” for about 2 months. This unfortunately, caused me to miss the entire Thanksgiving and Christmas seasons. After 2 months, wearing no aligners, I started Clarity 3M aligners on 1/16/20. I am about to start wearing RetainerClub.com aligners but the packaging has an allergy warning. I contacted my orthodontist, who referred me to Retainer Club. He said is not aware of any patients having allergic reactions to Retainer Club aligners. That is what he said about Invisalign and I know how that turned out:( Invisalign treatment began 11/18/19 and ended the morning of 11/20/19. I also posted about the allergic reaction online (don’t recall which one). Alison June 3, 2023 On Feb, 2023, after only 8 days of Invisalign, my son suffered his first ever tonic colonic seizure at 17 years old. He continued to wear the braces, even during the EEG, which showed brain activity leading to a diagnosis of epilepsy. He was placed on the maintenance medicine Keppra. Seven weeks and 5 days later, he suffered another seizure. At that time, he was still wearing them but we discontinued them and notified the orthodontist the following day. He hasn’t worn them since and hasn’t had a seizure since and we’re wondering if there is a connection. Invisible braces have shown to contain trace amounts of benzene, which can cause seizures. Edmond May 23, 2023 Is anybody experiencing uncomfortable bloating? If so any suggestions for remedy? I typically start getting bloated around the same time in the afternoon and it last all night. Nothing else has changed in my life except for wearing Invisalign! Liesa May 14, 2023 I had extreme fatigue! I mean extreme, had to stop treatment but the Ortho Doctor didn’t believe me that I was reacting to them!! And is still charging me $6,000!! Even though I stoped treatment after 2 weeks!!! Mari May 2, 2023 Anyone that has had any kind of reaction that is not normal, please go to FTC.gov and file a claim under product fraud. I filed my claim after finding out my seizures, trigeminal neuralgia, severe periodontal disease and loss of multiple teeth with need for implants. If you look up Hexane 1,6 you will find most of your symptoms. It’s toxic and not for oral use. Caroline March 8, 2023 Noticeable soreness, irritation and ulcers gradually happening after moving onto the nighttime vivaris retainers. Can’t stand it and removed them tonight. What a waste of money. I did wonder about my almost constantly swollen glands in the throat. Very validating to read of all the comments as I thought I was overreacting. Samantha March 5, 2023 I honestly feel like these plastic retainers ruined me. I couldn’t swallow to the point that watermelon and eggs were too hard to get down. I simply couldn’t eat. I started wearing them in 2018. I stopped after a little over a year when I realized they were seriously ruining my health. It’s 2023 and to this day I find my mouth super dry, gasping for air in the night, anxiety and still trouble swallowing pills. It’s sad when you get anxiety about swallowing 1 advil. I have never had trouble swallowing, and since these retainers I always feel like im choking. I dont even like to eat without someone being home. I was recently pregnant and couldnt even take my prenatal vitamins or an antibiotic that was prescribed to me. I used to be able to swallow 6 advil at once and never experienced any kind of anxiety in my life. Hopefully one day I will feel normal again. Huge mistake!!! I would never allow either of my children to use these aligners. Bren January 31, 2023 I have been using Invisalign for nearly 4 years now with no issues but I believe I have developed an allergy. I woke up about a week ago (I wear my nightly retainer) and my entire tongue is so painful and swollen. Right where the sides of my tongue touches the retainer are the worst. I also have a constant sore throat, not a sick feeling type but a pain leaking down from my tongue. Inside of my cheeks and lips are swollen as well. I took a couple nights off from wearing it and it started to go down a bit. Then tonight I tried putting them in for 5 minutes and instantly the swelling increased again. I am calling my dentist tomorrow. It is so uncomfortable and hard to eat and even speak. Nancy January 30, 2023 I wore my retains for 4-5 months and experienced a lot of the symptoms reported here in these comments; shortness of breath, stomach issues. etc. I did not associate them with Invisalign. I went in for an appointment and was told the retainers were not tracking correctly and I would need to have new ones and that would prolong the treatment. I had what they told me what a simple case. I did not want to go backwards and only had one more tray or so left, so I asked to have my case stopped and retainers made. It is when I went in to get the “buttons” removed that changed everything for me. They grind them off and smooth off the teeth. I had about 14 buttons. The next day my mouth felt like it was on fire and I had a sort of mucous film all over my mouth that I could not get rid of. I went back to dentist for a cleaning thinking it was a gum infection. They said no, and gave me a RX for Gerd. I didn’t understand how one day my mouth was fine and the next I had Gerd and my mouth was completely changed. I finally found this site and was relieved. I thought I was losing my mind. I wrote a letter to the dentist and the office letting them know I believe I had a reaction to the trays and the removal of the buttons and their material. No response from them. It has been almost a year and although I can breathe better and my stomach issues have gone away, my mouth is a mess with the film substance that will not go away. The only relief is when I am eating or drinking or chewing gum. The dental offices/ortho offices should be telling patients about potential side effects so they can make informative decisions about treatment. Elena January 21, 2023 I am a 40 y.o. old female and soon after I started wearing Invisalign, something bad to started to happen to my body. Initially, I could not associate that condition to Invisalign, because my dentist has not warned me of any side effects. First, I began to have rashes/itchiness on my body and face together with angular cheilitis. Then I started to have a feeling of a throat closing and tightness, difficulty breathing, hives on my chest, headaches, fatigue. I went to all types of doctors, undergone various blood tests, nothing abnormal was detected. At some point I was told I had a severe allergic reaction but yet I could not relate it to Invisalign. The things were getting worse and worse, I barely could breathe and my chest was covered by itching hives. Fortunately, I found this page, and took Invisalign out. My condition started to improve immediately. However, a month after I took them out, I am still not ok, some symptoms persist. Letting the doctors know about having worn Invisalign for 6 months, they prescribed antihistamines and blood cleansing IFs. I read some research saying that plastic dental braces could leach toxic harmful chemicals. I hope to recover one day sometimes soon and become the one I used to be. I wonder how many other people wearing plastic dental braces are not feeling well and are not able to find a cause of their condition. Concerned Mother January 9, 2023 My daughter had the metal braces but when finished, needed a retainer. Her Ortho provided the invisiline retainer for her top teeth (different type of retainer for bottom teeth). 24 hours later, I noticed a rash around one of my daughters eyes. It gradually moved to both eyes. It also included swollen lips. Has anyone experienced a rash using the invisiline retainer post braces? Tina December 15, 2022 I’m so glad I found this page and as I’m reading similarities between my reactions and others I know my orthodontist definitely didn’t have my best interest in mind when I consistently complained to her about these things. The lip swelling and tingling in my tongue was happening for awhile and the more intense night sweats. Then more recently I experienced something scary like someone else on here which was the scalp pressure! I thought all sorts of things and was getting so scared something was really wrong. I continued to tell my Ortho and she dismissed & continues to dismiss my issues to this day. I have a few more months until I finish my treatment but I’ve had these for almost 3 years now because she didn’t want to listen to me until the doctor finally say I needed a bone graft due to the aligners. She then ordered a new set to be made to correct this halfway through so now I have to keep these things in even longer in addition to my retainer at the end! I’m not happy with Sage Dental and how they handled this at all. They tried to make me think I was ridiculous for thinking this and at one point the Ortho and a few staff literally laughed in my face when I voiced my concerns. If you can avoid Invisalign and Sage dental in Plantation, Florida, please do by any means necessary! Peter December 8, 2022 lots of posts here is there a class action lawsuit coming? or are all these posts just fake? I can confirm i might have issues as well with invisalign causing stomach bloating and burning sensation in small intestine locaiton JENNIFER November 22, 2022 I’ve been wearing invisalign on and off since 2019 my mouth has become dry, lost my taste, and constantly have a film like presence in my mouth, any one else have this? M November 20, 2022 I started Invisalign in 2019 only to stop using it in two weeks due to unspecific or general malaises: throat, lymph nodes swelling, and headaches. I blamed the symptoms on my hypothyroidism and got back to using it for reduced hours. Noticed each time w/ Invisalign use, the symptoms returned, turned to m dentist for the issue—This is the weird portion of the dentist’s I thought: the dentist led me to a private room for my issue which the issue was handled quietly and “stealthily” avoided addressing the issue by suggesting the issue to slow use for the 5 years termed Invisalign. The unscrupulous practice left me in dark and the symptoms evolved over the years. In 2020, i used it 4 hours a day and not every day but in 2021, I ran to ER for heart palpitations, shortness of breath, tingling in all four limbs, and throat swelling. I finally decided to look into this product for the side effects but this website was not out front and up. In 2022, I ran to the ER two times and each time, symptoms were similar and worsening, recommending to see a cardiologist. I could see bright red blood in my spit, pain shooting from my throat to my head, and upper chest and back pain. I stopped using it and it took a month to feel a bit better. I will be seeing a cardiologist next week however, finding this webpage gave me a better insight into evolving symptoms since using the product. Here is one question though. Is it really a snake oil incident a stupid customer buys into? Or it is an undisclosed and overlooked product safety measurement by the Consumer Product Safety Commission that we pay tax to? People get hurt when regulatory bodies and law-making bodies are distracted. Where are the accountabilities for the product maker, and really these dentists who are unscrupulously promoting the toxic product at the expense of lives? How many people should be hurt to get the attention of our tax-paid agencies to act on it? Monique November 13, 2022 I am so glad I came across this website, I started my Invisalign a little over two weeks ago. The first night I had them in I woke up with what felt like hot flashes, night sweats and a headache. The next morning I felt an overall feeling of malaise and what felt like fast really fast heart rate. In general my blood pressure is always pretty low, and I’m a healthy person who eats well. Years ago I was diagnosed with IBS and Gerd. I thought maybe it’s a flare up? But how could that be? I learned years ago what diet works for me and I stick by it religiously. I then thought, maybe I’m getting sick? Well, over the past couple of weeks symptoms only worsened. I began having chest pains, on the left side of my body. Neck pains, and when I would eat it was kind of hard to swallow, my tongue also felt tingly on the tip. Then came the stomach pains along with feeling really bloated everyday. The last few days I also started having sores on my bottom inner lip, I thought maybe I’m biting my lip in my sleep or something? I literally did not put it together until yesterday evening, Saturday. I literally sat up and thought, oh sh** am I allergic to these retainers?? I took them out immediately, I finally slept well and all day today I have felt SO much better. These things were actually poisoning me! Now I have to call my orthodontist tomorrow and see what can be done? I doubt I’ll get a refund back. I will never wear Invisalign again and I definitely would never recommend them. Candi November 3, 2022 I experienced tongue selling and sores as well as mouth pain that would keep me awake at night. I gradually wore the Invisalign less. Then graduated to the permanent upper and lower lingual bar. Over a few weeks, I experienced mouth and tongue sores, my lips swelled and my tongue would bleed. I was told that one gets used to the bars so stuck with it. My lips burning was keeping me from sleeping, tongue sores, tongue bleeding, drooling, effort to swallow. My dentist told me that she has never heard of someone having a reaction to the bar before (come to find out it has nickel in it). We removed and it was instant relief. Over the next 24-48 hours my symptoms resolved completely. Since I did not have a lingual bar, I was told to wear my retainers. I waited a bit for my mouth to improve and have been diligently wearing them. I have developed sores on my tongue, tongue swelling and sharp stapling pain in the tongue that radiates to my throat, the tongue has a burn yet ache. My lips again swollen and painful. They feel like they are sunburned (they are not), I am constantly putting cortisone cream, Vaseline and taking Zyrtec but the hurt. In addition, I have been taking valtrex as initially I wasn’t sure I wouldn’t develop cold sores. I am again drooling. I noticed I have been feeling more short of breath to the point I felt I needed to have this evaluated before I go scuba diving to be sure I don’t have an event in water. Looking back while on Invisalign, I experienced more anxiety, i ended up in the ER once with GI symptom flare and once cardiac and under going echo and halter but now I wonder how much these things played into my last several months of not feeling well. The lip swelling, burning and pain as well as tongue symptoms, drooling and not sleeping for weeks to months due to pain is enough that I am done with this product. My dentist told me I am her only patient with any issues and that she is not aware of reaction to Invisalign. Clearly, I am not alone C. October 30, 2022 I used Invisalign for 7 days. It was day 7 when I realized my upset stomach, gas, bloating and nauseated feeling was associated with my new aligners. I went to the pharmacy on day 6 and picked Pepto and some other gas medicine which I have never needed before. Day 7 is when I let it go. I could not continue to get worse. Thank God, I have had to watch over my health closely in the past and notice changes and the association quickly. I wanted Invisalign for years, but it quickly did more harm than good. Cynthia October 30, 2022 I’m on my 6th set of aligners and have been feeling like crap off and on for sometime now, not sure if it started right away with the aligners but I do feel that they might be making me sick. I decided to Google it tonight to see if anyone else experienced some of the same problems and I’m saddened to see so many others are suffering. I’m seeing my dentist on Monday and can’t wait to discuss this with him. I’m hoping there is an alternative to the aligners I’m using. They really should make people aware of the possibility of negative side effects. Kristen October 13, 2022 I found this page after two months of searching for answers! I started Invisalign braces treatment on July 14, 2022. My allergic reaction to Invisalign braces began the week of August 8th, 2022 when I began my 4th pair of braces. My initial symptoms included an itchy scalp, scalp pressure, hair shedding, and general fatigue. As August continued, I had a general feeling of unwell, fatigue, scalp pressure, anxiety, and headaches. During this time, I went to monthly doctor’s appointments in August, September, and October. I had monthly dermatology appointments each month as well. All prescribed prescription shampoo and steroids to address my health concerns. I had lost 10lbs. I continued this treatment for 4-6 weeks with no improvement. We discontinued the treatment plan to see if the prescribed medication was causing irritation. There was no improvement with worsening symptoms. During late September, I was still experiencing general anxiety, feeling unwell, fatigue, scalp pressure, and headaches. During the first week of October, I had additional symptoms of difficulty sleeping and heart palpitations and my nerves felt entirely out of balance. On October 12, I took out my Invisalign and contacted my primary care physician, dentist, and dermatologist about this possible connection. All parties agreed to remove the Invisalign for a week to see if symptoms improve. h October 12, 2022 UPDATE !I ended up in ER last night again Tuesday October 10th again due to the reactions from the INVISALIGN TRAYS MATERIAL(chest pain & shortness of breath, swollen lymph nodes, swelling in jaw tissue , extremely painful lip swelling and blistering, my sitting heart rate was 141) due to the duration of exposure to the Invisalign toxins and the placement (i.e. in my mouth giving the toxins a direct route to my whole body for SIX months) the ER doctor does not believe that this will be a quick recovery . This was also confirmed by ER Doctor on Saturday, October 8 which was my first visit to ER after discovering that my Invisalign trays were causing me a severe adverse reaction. I had full face swelling, blisters in the lips and tongue, swollen lymph node, difficulty breathing, heart palpitations, migraine, extreme fatigue, brain fog. The ER doctor prescribed me 50 mg of prednisone for inflammation and performed EKG, stressing if I had any continuing issues to go back to the ER immediately. I removed the Invisalign trays on Tuesday night October 5 when whole face swelled. Saw my dentist Wednesday, October 6. The swelling was bad but persisted to get worse within my actual mouth and lips and lymph nodes. I am on my fourth day of 50 mg prednisone and the swelling has started to recede but the blistering which is in my lips and inside my jaw tissue is persistent, and ER doctor said it could take weeks for this to subside due to the duration of exposure from the Invisalign trays, which has been six months, and he could not tell me when I may return back to normal. When I first put the Invisalign in, I started to experience headaches had some swelling, but it would come and go as the months went on. I started to experiencing migraines severe upon waking up, severe, chronic fatigue, severe joint pain severe brain fog I was sleeping 12 to 14 hours a day. It has totally disrupted my life. My doctor has categorically logged all of these issues because we have done blood test and allergy test to try and figure out what the problem was in the whole time. The problem was the Invisalign tray , I have done research and found hundreds and hundreds and hundreds of other documentations of experiences like mine or worse. The Invisalign client agreement does not disclose any of these severe reactions being a possibility my dentist was totally unaware of any of these adverse reactions being an issue, and on the website, they do not disclose any type of adverse reactions. Had I had the knowledge to know that these symptoms were caused by the Invisalign I could’ve ended my treatment much sooner and save myself months and months of pain and suffering. I understand that the FDA gave Invisalign online technology a warning in 2011 about non-disclosure and non-transparency of severe adverse reactions in their patients. I discovered many other documented case similar or worse than my own. H October 7, 2022 Thank god for this comment page! I am a healthy 49 year old. I Began Invisalign on April 4, 2022. They give you four trays at a time before you are seen by your dentist for the next batch of trays. During the first batch of trays. I’ve started to experience headaches, fatigue, mouth sores, and rashes. All of which are unusual for me, but did not connect it at the time. My second batch of trays my headaches became worse, and I started to experience joint pain, and my fatigue was becoming worse, and brain fog. I was also experiencing mouth ulcers, but again did not connect it to Invisalign – on my third batch of trays my fatigue was overwhelming and rashes began popping up all over my body. Swollen glands and throat. I had severe brain fog along with migraines. I also had intermittent tongue swelling, and mouth ulcers. On my fourth batch I only used the first tray, and my lips started to swell, along with mouth, and eyes. So switched to the new trays from the same batch and my face blew up I realize that the issues I have been experiencing were directly from the Invisalign. I immediately stopped them two days ago 10/05/2022. Although the swelling is receding, I have internal blisters in lips – like chemical burns. The doctor has prescribed Prednisone and Zyrtec so we will see what the long term ramifications are. I have been slowly poising myself for six months. Along with all the other issues I have been experiencing sever joint pain from the inflammation that is being cased from my reaction to the material used in the trays which are manufactured in MEXICO! Upon deciding to do INVISALIGN at no point was I ever advised that there were these potential adverse reactions. Invisalign has contacted me but I have no idea how this will proceed. I have paid $7700 for the comprehensive system out of pocket and completed half returning the fourth batch of trays to them. They offered a hypo-allergenic trays to finish the treatment, but from what I have read they are no better, not risking what’s left of my health. And why wouldn’t they use hypoallergenic tray for everyone??? I would advise caution when using this treatment, had i been informed I could have saved myself months of misery and probably long-term damage. I cannot believe there has not been a class action lawsuit. George September 30, 2022 I am an otherwise healthy 43 year old male that is currently on tray 1 of the 2nd set of my Invisalign treatment. I first noticed I had developed this extremely itchy skin condition mainly on hands, feet and thighs after wearing my Invisalign trays overnight during my previous treatment tray. I initially attributed the cause of this itchiness and hives to food, dust, laundry detergent and everything else one would consider a possible culprit, until I lost tray 7 awaiting my current set that the itchiness and hives went away and received my current tray which I wore overnight. To my disappointment , The hives and itchiness has returned with vengeance. I am experiencing very itchy hands, arms and legs as well as swollen lymph nodes And hives. I have also lost over 20Lbs during this time and I am very curious to see if anyone else has experienced similar symptoms. George September 29, 2022 I am an otherwise healthy 43 year old male that is currently on tray 1 of the 2nd set of my Invisalign treatment. I first noticed I had developed this extremely itchy skin condition mainly on hands, feet and thighs after wearing my Invisalign trays overnight during my previous treatment tray. I initially contributed the cause of this itchiness and hives to food, dust, laundry detergent and everything else one would consider a possible culprit, until I lost tray 7 awaiting my current set that the itchiness and hives went away and received my current tray which I wore overnight. To my disappointment , The hives and itchiness has returned with vengeance. I am experiencing very itchy hands, arms and legs as well as swollen lymph nodes And hives. I have also lost over 20Lbs during this time and I am very curious to see if anyone else has experienced similar symptoms. lyssa September 3, 2022 started invisalign 3 years ago. Healthy female tri athlete of now 55 . started invisalign and had a few episodes of through tightening and a feeling of closing. expedited the time frame by skipping each tray so i only had to wear them 1/2 the time. i am now wearing the retainer every night by invisalign. I started having symptoms may 29th of 2019 with blisters on the bottom of my lips. it then progressed to constant burning and then swelling and then a white scaly blistery like and either purple or deep red color lips. These symptoms are constant and every day of my life since may of 2019. i Have seen 8 specialists and been incorrectly diagnosed with lupus, RA, and an auto immune called phemfigus . i am now going to change my retainer to a wire and no more retainers. I think this may be my issue. I have had 2 biopsy’s suggesting sun damage so i did cryo freezing on both lips. Swelling was better but now symptoms are coming back. Most importantly i asked my dentist who gave me the invisalign if i may be allergic. He said he gave me the hypoallergenic ones. When visiting with the representative of invisalign one day in the dentist office back in 2019 i had said how grateful i was to have an hypoallergenic one he relied ” I dont know what your talking about, we do not make a hypoallergenic one.” SCAM! Scott August 31, 2022 Some info for anyone with a previous autoimmune disorder. At the age of 61 decided to go with Invisalign program for teeth straightening. I’ve been struggling with a diagnosis of Rheumatoid Arthritis for over 20 years and have been able to keep my RA factor hovering around 30-40 with diet, exercise and other self help techniques. 3 years into Invisalign treatment my RA factor had jumped over 4 fold and I’m starting to experience severe brain fog, extreme low energy, worse joint pain/inflammation and lately dizzy spells. I’m one tray away from finishing my last “refinement” and plan on stopping completely in about 2 weeks. Total time with program about two and a half years. I will finish, if needed, with traditional braces. Interesting that I did a digestive/stool analyses where secretory IgA was high in digestive track but subsequent food allergy test was negative to all foods tested. Something is causing a immune response in the GI tract (as well as elsewhere) but not food, hummm wonder what that might be……….. Steffany August 14, 2022 When I started Invisalign prior to the pandemic, I experienced swollen gums, burning lips, and gum irritation and recession. My orthodontist advised that he had never heard of these problems and acted as though I was making bizarre statements.. I tried to restart after a break and experienced the same symptoms but also with an added sore throat. Invisalign and dentists clearly have invested a lot of money into this endeavor and have reaped profits. They are not being upfront about side effects. This needs to be investigated. As soon as I stopped Invisalign, my gum inflammation, lip and tongue burning, gum recession and sore throat disappeared. There’s some interaction with the plastic causing an immune response that is concerning. I’m out $5,000. Queen August 4, 2022 God has Answered my prayers To Lead me to this Group. All of this just hit me today. I just started/stopped my 8th tray. Besides my normal anxiety I have I truly felt out of my mind on Tray 3 I kept feeling THE DECREASE in my Energy and I kind of shrug it off thinking I just needed more B 12. Another week passes another tray still feeling the same. But a few days later I started feeling sick sick to my stomach and thought it was my IBS but this episode feels more intense and my meds stopped working (never happens). The Red Flags are coming so I’m just drinking smoothies and a few nights I use to dose off and forget to put back in and then I would feel a lil okay but kept wearing. I made a gastroenterologist appointment had ultrasounds done on my kidney, gallbladder, and liver to rule out and infection because I’m am not Myself at all physically and mentally because I feeling fatigued everyday at this point. Oh also had bloodwork done as well. I woke up at 4 am this morning and my mind is going I’m praying for some guidance and now I’m here sooo relieved but so Sorry that we are experiencing these reactions to these aligners. I’m working an alternative route and will keep you posted. I am no longer wearing those trays and can’t wait to be back at 100% Raquel July 24, 2022 Ever since I started Invisalign in 2019 I felt physically off. I developed an episode of tinnitus soon after. I also developed blurry vision and severe eczema on my hands. Shortly after I started the Invisaligners I noticed extreme changes in my menstrual cycle and my docs confirmed a uterine polyp which required surgery. When I asked the orthodontist if there was a possible connection between my symptoms and the plastic chemicals in the aligners he denied it. He did however order a hypoallergenic version of the trays and my eczema improved slightly, but did not go away until I finished the treatment. I am now wearing retainers at night but still have symptoms such as blurry vision and a puffy face. I believe these aligners are toxic for the body.. Jennifer July 21, 2022 I started Invisalign 4 days ago and have been nauseous and horrible headache since. When I take them out to eat I start to feel better. Then once I put them back in the nausea starts up . Was never given Any potential side effects. Concerned on losing alot of money but don’t want to end up in the hospital because no one was honest about the side effects. MS_Florida July 11, 2022 I completed my Invisalign in January 2022. In February 2022, I started experiencing numbness/soreness along the left side of my tongue and down the left side of my throat. I also have a swollen lymph node below the left side of my jaw. I have seen all kinds of doctors and no one has been able to help. After reading all these comments, I am now suspecting that all this may be caused by the Invisalign retainer I wear at night! My symptoms go away when I do not wear it, which may be an indicator that it is the root of the problem. matthew June 27, 2022 I used mouthwash to rinse and clean my invisaligns and never knew it could ruin my digestive system. there are no warnings on their website that I found. Anyone with Invisalign retainers on who uses mouthwash before bed is slowly poisoning themselves. I realized I had a problem after 3 days in the hospital and a quarter size blister in my mouth. Annie June 21, 2022 I am on set 19 and I have developed an issue swallowing. After reading all these comments I now see its probably the invisalign. Mary June 13, 2022 I had a bad reaction within several days of using Invisalign and admitted to ER with feeling of throat closing, at 58 yrs old no prior history with allergies. I do not recall being informed of this risk and am discontinuing the product . Mary June 13, 2022 I had a bad reaction within several days of using Invisalign and admitted to ER with feeling of throat closing, at 58 yrs old no prior history with allergies. I do not recall being informed of this risk and am discontinuing the product . Willy June 7, 2022 So glad I found this thread, woke up yesterday with what I can only explain as an extremely sore tongue all the way around the edges where it touches the Invisalign with swelling and a purplish/red bruising toward the front. I tried thinking back on anything I ate that could have caused this but I’ve never been allergic to any foods let alone any I had consumed recently. Only change is me starting Invisalign roughly 6 days ago. I called my dentist today and she said there are very few people who may have a reaction to Invisalign but to come in and have her take a look. I’m hoping this is the case and I can just stop using them and it will go away. Not sure if I can add comments to this one, but will follow up after if I am able. Deanna June 5, 2022 I developed a serious rash around my mouth then eyes which urned into eczema flares and spread to my hands afermore months. I had considered whether my braces were a factor because of the timing of it. I asked my dentist and we both thought they were likely not connected. I feel strongly this may be the cause of my ongoing severe facial rash as I have had it as long as I have had the braces. Seen many heath professionals with no results. Terry June 1, 2022 Very similar to others commenting on Invisalign, a few trays into my treatments I got what I thought was a cold, followed by a sore throat and then extreme shortness of breath. Then came an ER visit, the Doctor tried antibiotics, I seemed better, short time later another ER visit, I was tested for Covid – negative, chest x-ray, everything appeared normal. The Doctor/Pharmacist gave me a bag full of allergy medicine, soon after I’m back in the ER again. This time I told the Doctor about the Invisalign trays- she said take them out now! Breathing back to normal, no seasonal allergies, it was the Invisalign trays. Jessica May 30, 2022 Since wearing Invisalign in October 2020, I began getting red, swollen sore throats straight away, and routinely, after changing new trays. It went on for months and I’d brought this up to my orthodontist from the beginning, who found it hard to believe. Going forward, I washed all my new trays very thoroughly before putting them in to try and help.. it did a little. I am now in my final trays, and in a full blown mouth infection for 10 days, likely cause: Invisalign. I went to the walk in and then emerg a few days later. I haven’t been able to drink water or eat. I have been sucking on unlimited ice cubes for comfort. My mouth went from feeling like sharp glass all down my throat, to white patches and raw sores, to needing a steroid shot to get the inflammation down in my mouth, since pain relievers did nothing. So incredibly upset my concerns were never taken seriously, and it had to get to this point. I’m disappointed to see so many others with the same issues and the product has not been reviewed. Jessica May 30, 2022 Since wearing Invisalign in October 2020, I began getting red, swollen sore throats straight away, and routinely, after changing new trays. It went on for months and I’d brought this up to my orthodontist from the beginning, who found it hard to believe. Going forward, I washed all my new trays very thoroughly before putting them in to try and help.. it did a little. I am now in my final trays, and in a full blown mouth infection for 10 days, likely cause: Invisalign. I went to the walk in and then emerg a few days later. I haven’t been able to drink water or eat. I have been sucking on unlimited ice cubes for comfort. My mouth went from feeling like sharp glass all down my throat, to white patches and raw sores, to needing a steroid shot to get the inflammation down in my mouth, since pain relievers did nothing. So incredibly upset my concerns were never taken seriously, and it had to get to this point. I’m disappointed to see so many others with the same issues and the product has not been reviewed. Just May 29, 2022 I have had the Invisaligns in for about 6 months. Around three months I started to have what felt like onset of a sore throat.. Then the severe jaw popping , which my ortho said it wasn’t anything. My sore throat turned into this weird sensation like if I had smoke in my mouth that made me want to cough. Then it went to a weird feeling into my throat and upper chest. I went in for another round of try’s last week and told my ortho about it. She prescribed antibiotics. Went home, was woken up with this throbbing pain in front of ear. When to touch it and my lymph nosed had swelled up like water balloons. I immediately took out the liners and went to ER. Had a CAT scan , nothing, had blood work to rule out high white cell count, negative. Called my Ortho, she don’t believe it’s TMD, will see in a few weeks with ENT. Still have this weird sensation on tongue in throat… Sandy May 17, 2022 Wow, I am relieved to read I’m not alone. I woke up this morning with another sore throat and it came to me that maybe it’s the invisalign causing my issues. Sure enough I found this page when I began searching online. My orthodontist was terrible from the start, I should have been alarmed with the multiple page form I was made to sign waiving the orthodontist of liabilities. Although at no time was I told Invisalign could be unsafe. I had mouth sores from the beginning of treatment which I told my orthodontist were worse than the metal braces I had when I was younger. I had many of the attachments removed as I had constant sores in my mouth. Over the course of treatment I experienced and continue to experience severe fatigue, headaches, brain fog, dry mouth/lips, sore throat, abdominal discomfort and bloating, swelling around eyes, blurry vision, waking up feeling anxious, dehydration, and insomnia. This has persisted for more than two years. I have been to numerous doctors, some who run rests but mostly dismiss it. I finished the trays a year ago, however I still wear the nightly retainer. I will stop that immediately as I’m pretty convinced it is the cause of my suffering. What I’m curious about is if anyone is reporting these issues to Invisalign or to the FDA themselves. I am going to today. Breosha May 16, 2022 I’m having lots of similar symptoms that everyone on here has experienced. My throat is very sore to the touch on the outside and raw internally. I can barley swallow food without pain and discomfort! I got a steroid shot in my leg to help calm down the swelling and it helped but as soon as I ate spaghetti last night, my throat burned so bad with every swallow. I’m back to square one again. Nobody is being of any help! Can someone tell me what they’ve found out? 1 2 3 4 Older Comments Share Your CommentsFirst Name*Last NameEmail* Shared Comments*This field is hidden when viewing the formI authorize the above comments be posted on this page Yes No Post Comment I authorize the above comments be posted on this page Weekly Digest Opt-In Yes, send me a weekly email with the latest lawsuits, recalls and warnings. Want your comments reviewed by a lawyer?To have an attorney review your comments and contact you about a potential case, provide your contact information below. 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