Invisalign Invisible Braces Linked to Reports of Serious Allergic Reactions

Federal investigators have issued a warning to the makers of Invisalign for a failure to notify the FDA about potential problems with their invisible braces, which have reportedly caused some users to suffer extreme allergic reactions.ย 

The FDA Invisalign “invisible braces” warning letter was issued last month and accuses Align Technology, Inc. of failing to pass on adverse event reports to the agency in a timely manner. Some of the complaints, which include incidents of severe allergic reactions that have required hospitalization in some cases, date back to November 2007, but were not reported to the FDA as required by law.

According to the warning letter, allergic reactions to Invisalign braces reported by users include swollen and irritated lips, sore throats, a burning sensation on the tongue, ulcerations in the mouth and swollen lymph nodes. In some instances Invisalign side effects led consumers to stop using the braces.

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Spinal-Cord-Stimulation-Lawsuit

Federal regulations require medical device and drug companies who receive consumer complaints regarding potential side effects of their products to forward those adverse event reports on to FDA within 30 calendar days of receiving them or otherwise becoming aware of the incident.

In a response to the letter, Align Technology said in a press release that it was attempting to fully comply with the FDAโ€™s concerns, that they are turning over all copies of documentation requested by the agency and that they want to resolve the issue โ€œwith minimal impact on the company.โ€

Align Technology claims that the Invisalign system has been used by more than 1.3 million people since it received FDA approval in 1998. The product line includes Invisalign, Invisalign Teen, Invisalign Assist, Invisalign Express and Vivera Retainers. It was not clear from the warning letter which Invisalign products were associated with the reported problems and which were not.


176 Comments


Aimee
I also havenโ€™t experienced allergies like others, I have experienced nausea, heart palpitations, anxiety attacks, loss of sleep/broken sleep. This started at about a month into my treatment. Have been back and forth to emergency, doctors, cardiologists. Had multiple blood tests and stool samples. Everything comes back clear!! Have been feeling crazy!! Have now just realized that itโ€™s invisalign!! Started googling and found all these comments! Makes me feel not so alone. I will no longer be going on with my invisalign treatment!

Rose
I am currently on tray 8 of Invisalign, and my teeth are looking very nice. But, unlike most others on this site, I am not having tongue, lip, mouth issues. What I am having, however, is gastric issues, lethargy, and headaches. I have had multiple doctor appointments, X-rays, supplements, Gas X, upcoming gastroenterologist appointment, etc. I have had heartburn perhaps 3 or 4 times in my entire life, so gastric issues are foreign to me. I look as if I am 4 months pregnant (Iโ€™m 65), and am so uncomfortable by the end of the day, I have to wear sweats. The timing is such that I can possibly associate it with the use of the trays, and will stop wearing them beginning today. I am making an appointment with my orthodontist in going forward. I have little faith that he will agree with my assumption of issues with the Invisaligns but feel confident, after reading others experiences, I have gotten to the crux of my gastric problems.

Marsha
Iโ€™ve been using Invisalign for 8 months. I was so excited to finally have a an overbite and just make my smile look nicer. Iโ€™m probably older than most who get these liners but I couldnโ€™t afford braces when I was younger. I went to a highly recommended orthodontist and he showed me on his high end machine what my teeth look like and what it will look like after I get theses liners. I was ready to start. The first week of using the liner I felt nauseous and very tired but I attributed that to the saliva buildup I was experiencing and nothing more. As the months progressed I developed a horrible coughing which gave me terrible headaches and I felt weak and tired. I was coughing so hard I broke a blood vessel in my eye. I thought I was just sick. I went to visit my daughter in NJ for ten days. While there I was having terrible symptoms like pneumonia or flu so I went to an urgent care center and I was given flu medication even though the swab didnโ€™t show that I had the flu. I didnโ€™t get better and somehow managed to fly home so I could go to my GP who said I probably have pneumonia and he gave me cough medication which Iโ€™m still taking and will stop in a few days. I also took Mucinex and Tylenol. My husband has been very worried about my health so he did some investigating online and found others with my symptoms. All of which were wearing Invisalign. I sent an email to my orthodontist and he replied back to me saying that in all his 19 years of practice only 3-4 people have had a reaction and it usually occurs at the very beginning of using the liners and heโ€™d notice if I was allergic. He suggested I stop wearing the liners for 2-3 days to see if I felt better and to call him. Well I did take the liners out yesterday and I woke up this morning without the horrific coughing. I slept well last night. I canโ€™t tell you how much better I fell this morning. My GP set up an appointment a few weeks ago for me to see a pulmonologist about my coughing which Iโ€™m going to this morning. Iโ€™d like to know what materials are used to make the Invisalign liners. Thatโ€™s going to be my next question to my orthodontist. I hope that the plastic isnโ€™t harmful to my health long term.

Terri
By my email you will realize that I work in a health related field. I wore invisalign for two years and was very compliant. I asked before wearing them if there was any estrogenic material in the plastic. I was an 11 year survivor of Breast Cancer and I am careful about the amount of estrogenics in plastic. I was assured that there was not any. I had small issues but I was referred to Mayo for an MRI for unrelated issues and they saw a large shadow. After being an 11 year survivor to a low stage cancer, my lymph nodes in my neck are 91-100 percent (hghest range) estrogen. I am now battling metastatic Breast Cancer. Because of where my tumors are in my neck, near my thyroid, I asked pulmonologist is these inflamed nodes were in a pathway for something I would have had in my mouth. His answer was it is a perfect pathway and that was when they just thought I had swollen nodes. If I had not been a survivor they would not have done a biopsy of the nodes and found that they are estrogen based cancer. This is simply to raise awareness, and not to raise fear. Invisalign is made of MDI polyeurothane plastic and in 2007 the World Health Association said use of this plastic should never be discussed for oral use. Also, one study we found showed that MDI polyeurothane caused bronchial tumors and collapsed lungs in rats. I am writing this from Mayo where I am for more testing. I was diagnosed last year at this time. For me, it is not worth the risk.

Taracha
I started my Invisalign in March of 2019. I was to start on tray twelve this past Tuesday. Four months ago I started having issues where I felt dizzy sporadically. I do not wear daily glasses but my vision started to get gradually off. I can see but I have to focus manually. It is as if my brain doesn’t automatically tell my eyes to focus. Within the last month I have started to lose my sense of smell on some things. Then I started to have a foul smell in my nose that just comes randomly. It is as if it is inside. I even go as far as take a shower to clear my airways, and wash my hair when I smell it. It is still there. It smells like spoiled turkey or slight rot. I had sores in my mouth in the previous month, then sore tongue followed. I had a sore throat and constant runny nose. My orthodontist told me none of my symptoms were related to the invisalign. He advised they are safe. He never mentioned any hypo allergenic version. When I told him my sense of smell seems directly connected sense they are in my mouth. He damn near laughed it off as if it couldn’t possibly be true. In addition to all this, I have not been keeping track of things well. I am usually great with keeping track of things and order. But the last month I notice I have something like a brain fog. I don’t smoke. I don’t do any drunks. I barely drink twice a month. I workout and eat right. I have never felt this in 40 years. I feel completely off. I have been to my General practitioner, the Nurse practitioner, the gyno, and the Optometrist. They all have no idea why I am feeling like this. This entire ordeal is mimicking the Roundup cases that surface in the most recent news. For years the people were subject to what was told to be “safe” for them but look how that ended. I took those aligners out asap when I found this yesterday. I am taking all this back to my Orthos office and demanding some refund. I would rather have a small gap than a damaged neuro system. I mean WTH. Why wouldn’t this be apart of the normal warning conversation… oh wait, I didn’t get any warning information. And I DID ask about side affects. I will see what happens as I leave these off and let you all know. This is detrimental and needs to be addressed.

Becky
I had been wearing invisalign for a few months when I started experiencing dizziness, blurred vision, facial neuralgia type pain, burning in my mouth, hands and feet. I did not connect invisalign to these symptoms at first but noticed when I took the trays out for the few days the symptoms would subside. I have seen physicians to rule out other causes of these symptoms and all tests are negative. I have had these out for approximately 2 months and most of the symptoms have subsided but I still have some residual symptoms such as burning sensations in my hands and feet. My dentist and I have contacted the company but they are not responding to my telephone call or email.

Regrets
Don’t do it, prioritise your physical health over beauty I am 18 trays into my treatment of invisalign. I had dizzy spells ever since i started wearing it but i ignored it cause it wasnt too bad. Until now. My dizzyness and headaches is so crippling its hard to get out of bed, and i cannot concentrate on my homework because of my dizzy spells. It feels like a rock is shoved into my brain, i always feel groggy. I am speaking to my dentist about stopping treatment. I have seen the doctors but they have never heard of this before, and the dizzy medication they gave me does not help. Please reconsider if you are going to do invsialign. There are side effects they do not warn you about.

Sonia
I developed post nasal drip, allergies and rapid heart beats due to Invisalign. I always sound like I have a soar throat. After I developing all these symptoms I looked online and realized others have too.

Karen
I wore Invisalign several years ago. I wore all of the different trays that were given to me each time for the changes to be made. I finally had to stop because I felt like my left side of my mouth ( gum line) was always hurting. Told my dentist & he didnโ€™t say much. Went to an oral surgeon , who looked at my mouth & gums & said I donโ€™t see a thing wrong. On to a periodontist who again said I see nothing wrong. So after many years now Ive been suffering with a constant burning on the left side. Had I known that Invisalign could have caused this I would have immediately stopped wearing the trays. Now what to do??

Rose
Iโ€™ve had Invisaligns for 9 months. When I began I was completely healthy and competing in dance competitions. 3 months into the Invisaligns, I start getting tired, itchy skin, hair loss, sore throat, no more strength to do my dance competitions, muscle soreness, diarrhea. I went to several doctors and it took 6 months to find that it is the thyroid/autoimmune disease. I did some googling and found other people saying it is a side effect of the Invisaligns.

Jill
I was a healthy person prior to my use of invisalign. When I began use I came down with an upper respiratory illness, cough and sinus issues. My mouth was cut by the trays and I would have to saw the trays down and apply wax. My mouth was bleeding and sore. My dentist worked with me to continue. Before long I became sullen, pale and my hair became very thin and brittle. Even my skin became tough and I had terrible nausea and abdominal pain. I proceeded to have an elevated lipase and was hospitalized for pancreatitis. I was a healthy, normal weight full time working woman prior to this. I live a no alcohol healthy lifestyle. I ended up having my gall bladder removed but continued to have pancreatitis. When I realized I was either allergic to or being poisoned by the plastic trays in my mouth I removed them immediately one night when my heart was beating so slowly I thought I would die. I had a small intestine biopsy which showed unexplained allergic reaction. When allergy tested at a later date I am not allergic to anything else. My health is compromised to this day and I continue to have abdominal pain and nausea but my color is improved and my hair has recovered and my skin. I wish my dentist had known to have me stop use when I became so gravely ill.

Suzanne
I had invisalign for 9 months and had severe allergic reactions that my dentist said was impossible to react a month out. Almost died. Went to hospital 3 times, told doctors they basically laughed it off.Five years later now an autoimmune disease as my body couldn’t deal with 9 months of hives, facial swelling, itch that was so bad.

Marie
My daughter just spent 3 days back and forth to the ER for Epi shots, steroids, iv’s and other antihistamines due to Invisalign. The dentist never spoke of any possible side effects/reactions to this product. If she was not able to get to the ER those 3 times in 3 days, I could be reporting a fatality. Do not take any meds. medical devices without finding out any potential reactions. I thank God she is ok but her 4 young children and husband are also a wreck looking at what could have been a fatal outcome.

kerry
Started invisalign a few months ago. First 2 weeks seemed OK but within a few days of tray #2 I began to have ulcers in my mouth. I have had this issue in the past but nothing like this! I noticed the tray itself has sharp edges that cut the underside of my tongue. I stopped using the appliance thinking I would heal and then try again. The “buttons” that are placed on my teeth are also cutting into my oral mucosa. I’m going on around 5-6 weeks of constant outbreaks of excruciating ulcers, swollen lips. I am horribly fatigued just from dealing with the pain. Every time I start to heal from one outbreak another starts. I have had up to 4 ulcers in every part of my mouth and tongue at the same time (unprecedented). I seem to also have a gum infection in one area that I manged wuite well before with daily flossing etc. I have had swollen lymph nodes which I assumed was my immune system trying to deal with the overwhelming tissue damage, but now I have laryngitis (never had it in my life and I am 61). I am normally a very healthy athletic woman with lots of stress management skills but this is really upsetting. I see the dentist tomorrow, and I am pretty much DONE. Especially after reading all of this. I guess crooked teeth are part of my destiny. Of corse I have already paid 5000$!

Sarah
I started Invisalign and my TMJ pain got very severe with the 1st tray the pressure was awful- I was told I would have some pain so tried to push through – I looked up online and asked the Dentist- after trying muscle relaxers and pain meds my face neck and jaw pain got worse and the pressure in my sinuses was really painful then my nose started bleeding and cracked inside In several areas – I have a large scabs come out everyday now I had to stop treatment after 1 week and now 5 days later no relief from the TMJ pain Still on muscle relaxers and pain medicine They are removing the attachments Friday I feel like they shouldโ€™ve looked into this further before letting me purchase the invisaline as I answered the questionnaire as having TMJ Even though I was not having any symptoms prior to starting

carol
After 3 weeks of using Invisalign my voice changed. It has got a lot worse (I sound like a deaf person speaks). I can’t pronounce certain letters and I get out of breath when I speak. In addition I have had breathing and swallowing difficulties. I started the treatment in May 2018. I have since found out that there are life-threatening side effects to Invisalign! Had I known this I would not have taken the chance, and tried alternative orthodontic treatment (or none at all). As I haven’t had swelling or anaphylaxis I have continued with the treatment but I am now considering stopping it.

Heather
anaphylaxis from Invisalign – I had anaphalaxis reaction to the polyurethane and carcinogenic toxic isocyanate that makes up the tray material! I couldn’t breath! no one told me this could kill me! My throat swelled up, tight, heart racing, faint. It was horrible! I was scared! I was not warned this could happen! I went to the Invisalign website and it says they are non toxic..but that’s a lie. Im 39 and never had breathing problems in my life! why are these toxic ingretients not listed on the website? why wasn’t I told? The trays are taken out, no refund given on the trays, just more medical bills from the hospital visit. its beyond me that they would use this stuff in the mouth. Saying something is FDA approved doesn’t mean they went through product testing. I found reports on MAUDE (complaints reported to the FDA) showing MANY other people had been sent to the hospital because of difficulty breathing, sore throat, throat closing, dry mouth as well! For the billions Invisalign has made in profit they should offer organic materials. For example, use edible plastic made from seaweed. Its clear and can last 2 weeks before degrading. I know better than to put chemicals in my mouth. Especially cancer causing ones. This is probably why Invisalign makes it near impossible to find out what the trays are made of. Additionally, I read reports as far back as 2010 that the FDA warned Invisalign that the aligners were causing serious reactions in users. Ill never put that plastic back in my mouth ever again. Ill live with crooked teeth.

Dawn
I just began the retainer treatment and it is obvious I have an allergic reaction to the plastic ones they offer. I now wasted a lot of time and money for me teeth to end up crooked again because back in the day they made all metal with gold retainers which my orthodontist says he cannot make.

Teresa
I didn’t have a reaction for a couple of months but now my mouth feels like I rinsed with acid. Skin peeling off lips and even bled. Invisaligns screwed up my natural bite too. Thank God I have a great dentist. Lost a lot of sleep and caused me some major distress. Ortho didn’t disclose upfront how grueling it would be or the risk. Didn’t find out until I was to deep in to back out. Warning!!! False information about how easy and quick it is. Hope I haven’t compromised my health.

Sandra
I got first trays March 2016. Didn’t have much trouble, that I was aware was caused by the trays. I had been having headaches and neck spasms before the trays. After the trays the headaches became migraines, debilitating to say the least. At about tray 16 I noticed I was developing a rash around my mouth, in the corners and under the lower lip. Thought it was from the dry winter air. Tried everything to clear it up. I could feel the rash start burning. Did not equate it with the trays. It would go away partially and then I would feel the burning and know immediately that I would have a bright red semi-circle around my mouth. My tongue also started hurting and was irritated. It hurt even drinking water. The headaches were still persistent, and I was starting to loose my appetite as food tasted bad and it was increasingly difficult to chew, I developed stomach problems, a cough and dry heaves as a result. To top off all that, my dentist was never present when the trays were handed to me in the office and my attachments were never checked. I was on set 24 of 35 when I started complaining about the fit of the trays. At set 29 the dentist’s tech actually looked at my teeth and said that the alignment was off and took more impressions. When I went in to pick the next set up I was told that some of the attachments had been improperly placed and I needed some more attachments and would have to wear another 24 sets of trays. I, too, have sensitivities to the weirdest stuff and it got worse when I started this treatment. Never connected the two. Although I did have a bit of a reaction in the beginning just thought I was overreacting. But I did have bouts of facial hives, which I put down to stress and would take massive doses of Benadryl to counteract them. This seemed to work to alleviate the pain and anxiety that it caused to an extent, but I still did not equate the signs and symptoms with the trays. I did notice that as I went through the trays that they were getting dirty looking and discolored sooner and sooner. I started soaking them in Hydrogen peroxide after reading that 30 minutes or more would help clean the trays. When I had the tech take the impressions she said I would have to wear the current set, number 29 for another 3 weeks, which turned into 6 weeks by the time they received the new set of 24. I was concerned at that point about the bacteria and was soaking the trays every day. If the dental practice had been taking care of me properly some of this may have been avoided, but now after reading the stories of suffering and pain at this and several other sites, that I will not be going on with the treatment. It was a foolish idea I suppose to think that a medical professional would have my best interests at heart. The treatment cost $5,175, which I am of course still paying on. ๐Ÿ™ Hopefully the dentist will give me some sort of refund and remove the attachments. Am going in tomorrow. Wish me luck.

LESLIE
Shortly after beginning to use Invisalign, I got a rash around my mouth which has now spread to a few other areas of my face, including under my right eye and on the outside edge of one nostril. Thinking it might be an allergy to the plastic, I asked my dentist to get an ingredient list for the product. Approximately two months into wearing the Invisalign trays, my hair started falling out. Related? Today I went to my allergy doctor who said I was allergic to the Invisalign trays.

Jeanette
I haven’t had Invisalign yet, but my dentist is encouraging me to get…and I’m doing my research on teeth, jaw, and joints…I need to straighten my teeth because they are shifting and they are interfering with my joints, ie locked hip, and effecting my walk. So…wow I’m really glad I came into this website, now I’m at a conundrum… Anyways, I ran into this website online: Ask for an “Aligner 0” to go back to “normal” for those having physicial issue with the change in teeth position…You can read it here. https://www.realself.com/forum/invisalign-the-worst-mistake-my-life

Jamie
I began Invisalign last year. About three weeks in my mouth and throat started to burn. I contacted my dentist and he assured me be had never heard of this before. I asked him if possible allergic reactions have been reported he said no. My mouth continued to get worse, then I got what seemed like the flu, migraines, foggy thinking, blurred vision, fatigue, stomach issues, lymphoids swollen and my hair started to fall out. All of these symptoms are still happening. I have contacted Invisalign and they said they will change the trays to the hypoallergenic trays well it’s still happening. I have been on antibiotic after antibiotic, mouth wash and even got referred to an oral surgeon. The only time it gets better is when I do not weare my Invisalign. I spent a lot of time, money and illness on this. I’m so close to being done but I can’t deal with feeling this way. I’m a single mom with two special needs children. I don’t want to feel this way I want my life back.

Deann
It’s not just invisalign you need to worry about, learn more here: http://www.welcometodds.com/the-empowered-patient

maria
I posted a comment at 19th july 2016 about my nightmare with invisalign retainers. I had also a hard time getting an innofensive report about the symptoms I had when using the product. Finally I was given hypoalergenic retainers in the 5th of December.I falled immediatly in bed with flu ( coincidence) and at the second week my face was a furnace of skin rashes , swoolen eyes, itchy neck and fever.Conclusion: The hypoallergenic retainers are also heavily toxic.

MARTIN
My Dentist recommended Invisalign for TMJ my results have negative My bite has not been corrected and have been in severe pain

Jean
I had a reaction to the regular trays of Invisalign.. not being able to swallow! I got the hypoallergenic ones and didn’t have that problem. Although my hair has been coming out excessively!! I’ve worn these for 2 years now and after every test done with nothing coming back I’m finally wondering if hairloss is from these Invisalign?!? I’m scheduling to have regular braces out on. I’m desperate for my hair back and this is my only option left

MARTIN
My Dentist recommended Invisalign for TMJ my results have negative My bite has not been corrected and have been in severe pain

Jenna
I am floored! I am a dental hygienist. I have worked in dental since I was 17 years old and simply stocking rooms, and am now 42. It’s all I know, professionally. But, as I sit here, in bed, at 2am, with super swollen lips, I am in total disbelief! Here is my story. The orthodontist that we refer our patients to was so kind as to offer to realign my teeth for me, February, 16′! Note: After a first, successful round of Invisalign in 2003, followed by 9 years of wearing Invisalign retainers at night, religiously, and WITHOUT any side effects, my retainers had broken. After about a year and a half of not wearing them, my teeth had shifted, considerably, which brings us to today. Right about the time I received my first set of trays, in February of this year, I began to have a significant occurrence of hives. Full body, head to toe. I immediately began taking antihistamines, Benadryl, Zyrtec, Allegra, alternating. Had no idea, till this very night, that this could be from Invisalign!!! My hives were so intense that if I skipped even one day of antihistamines, I’d wake with an entire body full of raised, burning, itchy hives, ALL OVER. Because my insurance is horrible, and specialists are expensive, I chalked them up to seasonal allergies (that I had also experienced during a majorly stressful time in my life, 16 years ago, also resulting in hives), so, I continued to treat my symptoms with antihistamines. However, the seasons have changed, and I am still medicating, since February! Am still medicating, to this very day! Now, this lip swelling thing has been off and on, and getting progressively worse, throughout all of this, but I hadnt connected it (till tonight) to the retainers. I thought it was my lip balm. Thought, maybe, the face masks that we wear at the dental office? So, I have discontinued use of both of those things, for about a month, now. (Wearing a face shield, instead of a mask, while treating patients). No recent swellings of my lips, so I hoped I had solved the problem. Till tonight. Put my new retainer in, around 9pm, tonight (tray #3 of 7, for this newest ‘revision’), and just woke with a hugely swollen lip, swollen tongue (both, rt side), and extreme tightness in my chest! So, I began to search the Web to see if there were any others out there, like me, with this same experience. (Imagine my surprise). And, yes, I also have been having inflamed lymph nodes in my neck (thyroid area) and a few, the size of golf balls, a few months ago, in the back of my neck! Chalked those up to a history of cat dander allergy, or seasonal stuff?! I am astounded that after reading all of your posts, (there are many!), these crazy symptoms are definitely related, and due to the Invisalign trays!!! It all makes sense now! I am in shock. And, I must say, a bit embarrassed, that I didn’t connect all these dots till now! Thank God for the Web and for all you amazing people that took the time to share your stories. Forgot to add that my lips have also been significantly dry and burning, lately. And, with removing lip balms, of any kind, from my routine, they have felt even worse! So, now what? Going to call my orthodontist as soon as the sun is up!!! Oh, and I’d better get these retainers out, stat! Sincere thanks to you all!

Daniella
I got a plastic retainer my lips swelled I had seizures and emergencies now im disabled in college wondering how I can find enough to eat.

TP
I have had my Invisalign since Jan. of 2016 and I’m at the refinement stage now. I would be done, but have to do a few more tweaks. I have had the worst migraines of my life during the course of this treatment and I thought it was stress related. I had to be put on prescription migraine medication and even still when I get them I am paralyzed with pain. I truly believe these retainers have caused it. I’ve also been dizzy, light headed and get extreme motion sickness. I never used to experience any of these things until a couple months into my treatment. They have to be related. Looking forward to getting these things out and detoxing/cleansing. Hopefully symptoms will resolve when I do.

Bun
Hi There! I had most of the symptoms in the beginning, but I noticed after a month of suffering in my bed from fever, headaches, servere cough, swollen throat, low energy, tired, and allergies, I thought it was from food poisoning, since a friend and son had it. I have never been that sick in my life, I thought maybe it was in the air. Someone mentioned the loss of taste. I have that with the loss of smell. I now have this strange smell and it’s hard to enjoy food. It’s like a cheesy/chemical taste and smell, its stronger depending on my surroundings, like smoke the smell gets worse. I also went from 145-150 lbs to now 121 Ibs. Later I had no idea what was causing everything. I thought maybe it was Cancer, Candida, or Diabetics. I wonder if it affected my mental health, since I was confused and had a hard time remembering things. I am so grateful to The Lord for directing me to look closer to the dangers of the trays. I’m surprised the dentist did not mention the hypoloallergic trays, or share other people’s side effects, and share the chemical ingredients. I removed them three days ago, now experiencing itch and headaches. My ortho. office recommended a fluoride toothpaste: Colgate, PrevilDent 5000, which I will stop using as well, and go back to Tom’s non-fluoride toothpaste, I heard fluoride is very bad. Dentists say use only a little bit, but if you brush your teeth more than twice a day, the fluoride adds up. Thank you all so much for your comments!!

Phyllis
I wore the Invisalign braces without issues for 1 1/2 of the 2 years that I was scheduled to use them. Gradually I started feeling “off” and it got to the point where my throat felt tight and I felt spacey and like I was having a panic attack. There was no reason to have a panic attack and they had never happened previously. I went to the fire station to have my vitals checked. Oxygen levels were fine, heart rate up a bit and having PVCs – they suggested I see an allergist. I made it home; something told me to google Invisalign and allergic reactions. I took out the braces and took a Claritin. Started to feel more normal after half hour or so. Left the braces out, had to take the Claritin daily (still do even though the braces have been out now for many months) plus additional vitamin C for the anti histamine effect. Did see allergist, explained what had happened. She did some tests; ended up doing a nebulizer treatment to increase lung air flow. A blood tryptase level came back elevated; this can be associated with an increased risk of severe allergic reactions. My younger sister, who gets allergy shots weekly, also tested with an elevated tryptase level. Interestingly enough, I had additional labs, IgE and RAST testing and they all came back completely NEGATIVE. No food or environmental allergies (they don’t test for chemicals like whatever is used in the braces). My orthodentist had a retainer made for me, stainless steel with some type of plastic (different from the invisalign material) for the part that is in the back of the retainer. Within minutes of inserting the retainer my throat tightened so I yanked it out and immediately took 6 additional grams of vitamin C. Symptoms eased after half hour or so. When I read online about some other people who had had reactions, they commented about the sense of panic and anxiety; some had local swelling or blisters. No one had warned me about any of this before I started. I now notice on the TV commercials for the Invisalign there is a caution about possible rare allergic reactions. Too bad I couldn’t be refunded for the unused trays. This treatment is EXPENSIVE.

Laura
Has anyone experienced feeling overheated? Excessive sweating? Difficulty breathing or asthma like symptoms? Since I started Invisaligns a year ago I have excessive sweating day and night. I have never had trouble breathing before I started wearing Invisaligns. Then I see this site. I will read the MSDS sheet on the plastic. Why wasn’t I given any material that would warn me of this?

Gina
I started wearing Invisalign in October 2015. I experienced dry lips from the very start, but it was fall and the furnace was starting to run so I thought it was just that the house was dry. Now it is July 2016 and my lips are still dry. If that were my only problem, I would be fine with it. However, I have been getting recurrent cold sores. These cold sores, if that is really what they are, don’t respond the Abreva or Lysine like previous colds sores did. I have also gotten them within a few hours of having impressions taken for the Invisalign. That got me to wondering if the cold sores and dry mouth was caused by my Invisalign. I did a search and found this site. I am on my second set of aligners and about two and a half months away from finishing so I might just try to tough it out. I am hoping that the retainer won’t cause the same problem. At least I will only have to wear that at night. Does anyone know if the retainer is made out of the same material?

Dana
I canโ€™t get a refund because of no official doctorโ€™s report? What if people donโ€™t have a health insurance like me? I should pay few thousand dollars by cash to find out the cause of the symptoms, (Iโ€™ve already talked with friends and doctor friend, many people they paid few thousand dollars with health insurance to see the doctorsโ€ฆ) If the return money is only $250.00, I canโ€™t spend more than $250.00 dollars by cash, right? Please let me know how much will be the refund, then maybe I will go to see the doctors. If you have an official letter from clear correct representatives, could you forward me that? or Can I talk / send a letter to clear correct directly? BTW, can you replace the trays with hypoallergenic version? Thank you, Young

Jennifer
I had a similar reaction within minutes of getting Invisalign . My lips and gums burned , I was dizzy , had flu-like symptoms( sore throat , achy , chills ) , and my neck got stiff . I went to the ER and asked me what I had today and I told them Invisalign was done and they said it was an allergic reaction . Very scary !!! Is anything being done about this ?

maria
I’ve been using Invisalign bracets since july 2015.I was stuck in bed for almost 2 month with severe abdominal inflammation and the cause was not found. I was diagnosed with burnout in december and further in february. In may I stopped working already taking antidepressants.I could not move.Dizziness, foggy vision, strong headaches, chronic fatigue, pain in the bones and veins were some of the symptoms. I only associated that with Invisalign after reading exactly the same reports in internet. After quitting Invisalign I recovered.

Elle
I decided to get the Invisalign Express 10 (five trays over 10 weeks) for some minor shifting that’s occurred as I’ve gotten older (I had braces in middle school back in the 80s). Although I did experience allergic reactions, mine were isolated to my mouth area alone, specifically my lips, corners of my mouth and the skin surrounding my lips. It definitely caused some pain and discomfort, but it was so unsightly and very noticeable. The dry mouth with wearing the trays was beyond annoying, so I initially thought the chapped lips and mouth irritation was a result of that. One mouth corner was really irritated…I thought I was getting a cold sore, but never happened. Took some Acyclovir just in case, no improvement. Also took Lysine supplement and applied Lysine ointmemt, also no help. My lips felt hot, and I had a red ring on the skin surrounding my mouth, which also felt hot. I could always tell when the redness got worse without looking because of that hot feeling. One corner of my mouth was just raw. I was afraid to open my mouth that much because the skin felt so tight, I thought it would crack and bleed. My whole mouth area just hurt (but not inside…no sores, no swollen tongue). I also don’t recall any coldlike symptoms, but I also have allergies so maybe it didn’t register with me. I Googled for dry mouth/irritation with the Invisalign for suggestions and learned about the history with allergic reactions to invisalign and that there was a hypoallergenic version. I hit Invisalign up on Twitter asking for advice bc I was having a reaction. They responded quickly, told me to stop wearing the trays, contact my dentist and follow a link to fill out infomercial they could contact me directly. Had a dentist appnt a cple days later and showed him the problem. Invisalign replaced all of my trays with the so-called hypoallergenic tryas. Same thing happened within 8 hours of wearing those. They said they have, one more option/type of tray and I’ll get those in a week. BUT, this 3rd option is simply the first or at least a previous version. And the only difference b/t the 1st trays I got and the “hypoallergenic” is a slightly different polyurethane. At least Invisalign has offered to give me a full refund if this 3rd set doesn’t work. Still sucks bc my teeth have already moved and my night guard no longer fits and it’s $800 for a new one. I wish I never started with Invisalign at all. The redness still hasn’t fully healed and still often gets inflamed on one side, and that’s after only having the 2nd set in for 8 hours over the past three weeks or so. Starting to think it will never go away. The Rx my dermatologist give me for it is over $300 (not covered by my insurance…and it cost me a $70 co-pay) so I can’t afford to fill the script.

marion
my name is marion i had the same problem with invisalign the orthodontist that i had did not care his name was gersh i went throught the treatment it has been a year and i am still having problems excess saliva can any one helpme i hope you can contact me so we can talk

debbie
got my first tray on March 3rd.A few hours after wearing the first invisalign retainers I felt my tongue burning.My lips were swallen and had blisters on my tongue and lips. I wore the retainers about 32 hours thinking that I might be a crying baby.The cement put on my teeth tore my skin all over. the sharp edges of the retainers cut my skin and tongue or so I thought. Went to see another dentist who made the cement bumps smoother and cut part of the sharp edges of the retainers. I wore the retainers for a another day thinking it would be better which never happened. Called my Orthodontist and he reassured me things would be all right. Could not stand it and took the retainers out for a few days. The symptoms subsided a lot but did not completely disappeard. That was when I thought that I have an allergic reaction to the retainers. After the symptoms calm down I started wearing the retainers again for about 3 days which were a nightmare. All the symptoms from before and many others appeared,like head aches,ears aches,jaws aches,nausea,stomach cramps and diarrhea ,mouth ulcers.dried mouth,dizziness. I stopped wering the retainers for 2 days and the symptoms got a bit better. Called my Orthodontist again and he told me to wear the retainers in intervals of 2 hours to get used to them and that I should see him to try to fix the retainers. When I told him that I have an allergic reaction he said that it is impossible because my retainers are Hypoallegenic. I put back the retainers back on my teethe and the symptoms were back within a short time like minutes. I am so mad at the orthodontist for dismissing my complains. I am going to see him in a few days and try to get a refund for my money.Without any doubt I am not going to wear these invisalign retainers.

Xiomara
Hello, Can’t sleep 3am. I started using invisiline in Oct 2015 just before we went on a cruise. Three days in I woke up with a swollen lip. Since my immunity is low I thought I had been parting to much and my body could not take it. A few months later a woke up with swollen lymph nodes and felt like a cold and with a swollen lip. I have small bumpd on my lips and they also peel. I through maybe a was having as reaction to alcohol, stress, starting my cyclkr or oils that I started using. A few weeks ago I call my orthodontist and told them about my lips situation and they stated that the trays did not cause my symptoms that I have cold sores. After reading this took of my trays.I will be going to the office and talking to my orthodontist. My teeth are fine the reason I was wearing them is because I have tmj. Thank you so much for this site.

Naoka
I started my invisalign december 16th, 2015. I first noticed pain in my back so I assumed it was my lungs. Since it was winter time I figured it was just a bug I had caught. Four days into my invisalign the pain in back spread to my chest. I started having a shortness of breath and I also felt completely exhausted even though I was not tired. That same day I noticed a swollen lymph node under my armpit and tiny sores on my gum line, however it wasnt where the invisalign touched. I then googled mouth sores associated with invisalign and found this website! I immediately took them out. Most of the symptoms have subsided but I still feel like there is something stuck in my throat and chest. I seen my ortho today (Jan 5 2016) and he assures me that it is not invisalign but I dont believe him and Im not willing to chance it again like he suggest I should.

Brandy
I started Invisalign and shortly after started having shortness of breath and gum irritation. Once I reached my 3rd Trey or so I noticed a big purple spot was forming on my upper lip as well as my gum where the Invisalign touched. I was concerned as to what may have caused it. I immediately thought it may be my Invisalign but once I mentioned it to my orthodontis, he dismissed the idea of it being an allergic reaction so I went to the doctor and they ran many tests which came back normal. I demanded they send me to a skin specialist and they diagnosed me with dermatitis which is an allergy/allergic reaction. She advised I stop using Invisalign and after a month of discontinuing my huge purple spot on my lip has faded tremendously to where I don’t have to wear lip stick to cover it. But it is still slightly noticable. Not to mention my testh are now Crooked because I had to doscontinue. So much money wasted I pray they make this right by refunding my money or something this is insane how much stress I have gone through trying to find out why I am having a hard time breathing let alone have a huge purple spot on my upper lip that can’t be disguised with the darkest lip stick smh dot ever do Invisalign so not worth it!! I may have to sue this is insane all these complaints and I wasn’t even notified that there are potential health risks associated with Invisalign.

Cara
Luckily I stumbled upon this while searching if the marble size ball under the inside of my lower lips is caused by invisalign. I’m so upset. I have not had chronic chapped and peeling lips since I was 20. I’m 39 now. Also, being someone who practices yoga I like to do deep breathing exercises… not since starting Invisalign nearly 2 months ago. Today while sitting at my desk I felt a marble size lump inside the skin between my lower lip and chin. I freaked out! I just took my trays out, and will not do anything else until I speak with my Orthodontist. Why doesn’t everyone get Hypoallergenic Invisalign? This makes no sense!

Shirley
I didn’t know this site existed until I google Invisalign and sore throat. I have been wearing Invisalign for six weeks now. Every seven days I put in a new tray. The fifth week I noticed a different taste on the plastic. The next day my lips were swollen tongue swollen throat extremely sore face itch tongue numb face swollen and inside my mouth was very red and sore and I was nauseous couldn’t eat. Went to the Doctor he treated me for allergies. Four days later it flared back up. again I was treated for allergies. Tuesday l put in my sixth set Wednesday I was back been treated for allergies again. I prayed went to Walmart bought me some Lysine for my lips. I went home took the Invisalign off and soaked them in in some dawn dish washing detergent drank me some warm lemon water swished some warm salted water around in my mouth several times put some ice on my lips then I put the Invisalign back in my mouth after an hour. Today is Thanksgiving. I have no problem eating and I have no symptoms. I will wait until Saturday to see if what I did work since I flare up every four days. Plastic never been good not even with bottle water. I’m drinking plenty of water because those Invisalign are full of bacteria in the mouth. Glad I found this site!

Jodi
I cannot believe that I just found this site. I joined the Invisalign bandwagon in 2012 and had many issues with the trays cutting the inside of my mouth. However, my plight escalated to the extreme. After almost 1 1/2 years of the Invisalign saga of discomfort, I finally said enough is enough! My tongue was killing me 2 months before I stopped. I believed it to be an irritation from my tongue rubbing up against the trays on the left side of my mouth. However, after we stopped the treatment, my tongue persisted to hurt immensely. I ended up going to an orthodontist (a dentist applied the Invisalign), to help put my teeth back in place and hopefully stop the discomfort in my tongue by doing that. However, after being n braces for 15 months, trying different tweaking methods to try to give me some relief, there has been only a little relief. My tongue burns constantly. I went to an ENT specialist to check my tongue and he said it was perfectly healthy to the eye. I went to my dentist and he said the same thing about the health of my tongue. BUT, I feel the continuous friction of the rubbing up against my teeth. Finally, my dentist today believe that there is some nerve damage caused by the invisalign that is giving me the burning sensation. What to do now? I am still searching for that answer.

Marilu
I started Invisalign in May of this year, right after using the tray I started having sore throat , dry chapped lips, swollen lynfo, I felt like I’ll, I was feeling nausea and once during a meeting for work I had to run to the bathroom as I felt extremely nauseated and felt I had to throw up. Well the worse has still to come, my immune system started reacting to many things and I suddenly also developed metal allergies and I was feeling metal in my mouth and was giving me bad allergic reaction as my throat felt like flooding up so I immediately was getting Benadryl. Well after 2 weeks I started understaffing that it was Invisalign that was causing this, so I tried to not wear the trays for about 3-4 days and my symptoms were great,y improving so I called my doctor and he said that it is rare but that the have hypoallergenic ones, I absolutely did not want to try them, I was dine with this. Well the main problem is that it seems that the plastic trays intoxicated my body and my immune system got more sensitive and started reacting to almost everything which brought me several times to the hospital and has to take cortisone and other medicines to call this down. After almost 5 months of stopping using the Invisalign I still have the consequences of the 2 weeks I have been using them. Why they do not give the hypoallergenic ones since the beginning? What there is no warning about these reactions? Invisalign is a scam, I would not suggest it to no one. I think it would be right to sue them, it is not correct for us to go through something horrible like this. Good luck to everybody!!

PN
I only lasted 5 days. I also wish I had seen these comments beforehand. I was in excruciating pain by my 5th day. The burning sensation in my mouth and tongue was intolerable. I lost 5 lbs in 4 days because eating was so painful. By the 5th day, I was unable to speak. I had researched Invisalign prior to getting them but had never heard of allergic reactions or the burning tongue reaction. I ended my treatment on the 5th day and was so relieved to be free of the pain. My entire system felt off kilter and is still recovering. How sad that I spent $3,800 to endure 5 days of pain. Absolutely regret my decision, however, my dentist may refund a small portion.

Laurie
I started invisalign in August. I wish I would have read these stories sooner. I had them in and the next day I started getting a tingling in my lips , they would swell, peel and are so dry. I was not able to to go past the 2nd tray. I was never warned that some people can have an allergy to them. They said to stop if I wanted and they would order hypoallergenic tray for me. THERE ARE NO HYPOALLERGENIC INVISALIGN. The minute I put the so called hypoallergenic trays in I felt the same thing immediately. So I took them out and went to an allergist. he said it may take 1 to 3 months for the symptoms to go away. So Called the dentist and I was told that they are not really hypoallergenic but run through again to get rid of more of the product . I would have never put them in my mouth again if I had known. So pissed. My lips swell, burn , tingle and peel it is 2 months now.

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