Combination of Tekturna, Other Hypertension Drugs Gets FDA Warning

Federal health officials warn that the blood pressure drug Tekturna and similar medications should not be given to diabetics or patients with kidney problems in combination with drugs known as ARBs and ACE inhibitors, which are also used to treat blood pressure problems. 

The combination of Tekturna and other drugs containing the active ingredient aliskiren with angiotensin converting enzyme inhibitors (ACEIs) or angiotensin receptor blockers (ARBs) can cause kidney impairment, hypotension and hyperkalemia, the FDA warned in a drug safety communication issued on April 20.

The announcement has led Novartis, which manufacturers aliskiren-containing drugs, to announce that it will phase out the drug Valturna, which is a combination of Tekturna and the ARB drug valsartan. Valturna will be available through July before it is permanently removed from the market.

Did You Know?

AT&T Data Breach Impacts Millions of Customers

More than 73 million customers of AT&T may have had their names, addresses, phone numbers, Social Security numbers and other information released on the dark web due to a massive AT&T data breach. Lawsuits are being pursued to obtain financial compensation.

Learn More

Tekturna (aliskiren) is manufactured by Novartis and was first approved in the United States in 2007 for the treatment of hypertension. Other drugs that contain aliskiren include Amturnide and Tekamlo. There were about 2.4 million prescriptions filled for aliskiren-containing drugs in 2011 in the United States, according to the FDA.

The warnings include a contraindication for the combination of drugs in the treatment of patients with diabetes and a warning against its use for patients who have already have moderate to severe kidney problems.

The FDA called for patients to continue using the drugs at least until they talk to their doctor and to make sure their health care professionals know if they are taking any ACEIs or ARBs at the same time they are prescribed a drug containing aliskiren.

The FDA warning came after a preliminary review of a study called ALTITUDE, which was ended early due to the high rates of kidney problems, hypotension and hyperkalemia observed among test subjects. The ALTITUDE trial involved the use of Tekturna along with ACE inhibitors or ARBs. As a result, Novartis says it will cease promoting the use of Tekturna in combination with those drugs in any patients, in addition to the phase out of Valturna.

0 Comments

Share Your Comments

I authorize the above comments be posted on this page*

Want your comments reviewed by a lawyer?

To have an attorney review your comments and contact you about a potential case, provide your contact information below. This will not be published.

NOTE: Providing information for review by an attorney does not form an attorney-client relationship.

This field is for validation purposes and should be left unchanged.

More Top Stories

Leadership Development Committee for Suboxone Dental Injury Lawyers Established in Federal MDL
Leadership Development Committee for Suboxone Dental Injury Lawyers Established in Federal MDL (Posted today)

The U.S. District Judge presiding over all Suboxone lawsuits has created a mentorship program to use the litigation to provide some attorneys an opportunity to gain experience in handling complex federal multidistrict litigations.

Gilead Settlement Resolves 2,625 HIV Drug Lawsuits Pending in Federal Courts for $40M
Gilead Settlement Resolves 2,625 HIV Drug Lawsuits Pending in Federal Courts for $40M (Posted 2 days ago)

Gilead says it will pay $40 million to resolve HIV drug lawsuits over Truvada, Atripla, Viread, Stribild and Complera pending in the federal court system, involving claims that the the company sat on safer formulations of the drugs for years to increase profits.