Nexium, Prilosec and Other Acid Reflux Drug Lawsuits


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Side effects of Nexium, Prilosec and other blockbuster heartburn and acid reflux medications have been linked to a risk of acute kidney injury, chronic kidney disease and potentially kidney failure. However, it appears that inadequate warnings may have been provided to consumers and the medical community.

ACID REFLUX DRUG LAWSUIT STATUS:: Product liability lawyers are reviewing potential Nexium lawsuits, Prilosec lawsuits and other claims involving side effects of acid reflux drugs known as proton pump inhibitors (PPI). Potential claims are being reviewed for users who suffered any of the following injuries:

  • Acute Kidney Injury
  • Acute Interstitial Nephritis
  • Chronic Kidney Disease
  • Kidney or Renal Failure

As a result of the drug makers’ failure to warn about the link between acid reflux drugs and kidney problems, financial compensation may be available for users of any of the following proton pump inhibitors:

  • Nexium
  • Prilosec
  • Dexilant
  • Protonix
  • Prevacid
  • AcipHex
  • Vimovo
  • Zegarid


OVERVIEW: Proton pump inhibitors (PPI) are a popular class of medications used to reduce the amount of acid in the stomach, treating gastroesophageal reflux disease (GERD), heartburn, acid reflux, ulcers in the stomach and small intestines and inflammation of the esophagus.

The class of medications includes some of the most widely used drugs in the United States, with brand-name, generic and over-the-counter versions of Nexium, Prilosec and other drugs generating over $14 billion in annual sales.

The medications have been aggressively promoted as safe and effective, suggesting that users face little risk of side effects from Nexium, Prilosec or other acid reflux drugs. However, a number of studies have suggested that users may face a potential risk of kidney injury, kidney disease or kidney failure.

In December 2014, the FDA required new acid reflux drug warnings for Nexium, Prilosec and other proton pump inhibitors, indicating that some users have experienced acute interstitial nephritis, which involves an inflammation of hte kidneys that may lead to chronic and long-term injury. However, it appears that the manufacturers knew or should have known about the potential kidney risks with acid reflux drugs and failed to provide adequate warnings and information.

NEXIUM KIDNEY INJURY RISK: In April 2015, a study published in the medical journal CMAJ Open indicated that Nexium, Prilosec and other proton pump inhibitors are an under appreciated cause of acute kidney injury, finding that some users may be 2.5 times more likely to develop this condition that involves abrupt loss of kidney function.

Researchers warned about the link between acid reflux drugs and kidney injury, indicating that the condition may not be readily attributed to the treatment.

The study involved a review of data on 300,000 people aged 66 and older who started acid reflux treatment with a proton pump inhibitor from April 2002 to November 2011. Elderly users were found to be more likely to suffer acute kidney injury on Nexium, Prilosec or another PPI, when compared to users who were not taking the drug. Similarly, the risk of acute interstitial nephritis from the acid reflux drugs was tripled for those users.

CHRONIC KIDNEY DISEASE FROM PPI ACID REFLUX DRUGS: In January 2016, a study published in the medical journal JAMA Internal Medicine examined whether this popular class of drugs may also increase the risk of chronic kidney disease, which is a longer-term condition that may lead to kidney failure and the need for dialysis treatment or a kidney transplant.

Researchers reviewed data on 10,482 participants in the Atherosclerosis Risk in Communities study from February 1996 to December 2011, looking at self-reported heartburn drug use and outpatient prescriptions.

The study found that there was a 45% increased risk of chronic kidney disease with proton pump inhibitors (PPI).

NEXIUM BONE PROBLEMS: In May 2010, the FDA warned that there may be increased risk of bone fracture from prescription strength heartburn drugs like Nexium. The FDA required an update to the warning label about the risk of fractures from Nexium and other drugs in the class. FDA investigators determined that the risk of fractures is dose-specific and have not applied the Nexium bone fracture warning requirements to the over-the-counter versions of Nexium or similar PPIs.

Although multiple studies suggested that users may face an increased risk of bone problems from Nexium, AstraZeneca continued to market the medication without warning about the risk of bone deterioration, osteoporosis or fractures, according to allegations raised in several Nexium bone fracture lawsuits filed around that time.

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  1. James Reply

    I have been taking NEXIUM for about eight years. I have Rheumatoid Arthritis and Osteoarthritis. Could the NEXIUM have caused the aching in my right hip and legs?


  2. Denise Reply

    I have taken Nexium and Prilosec since 2001. I was so excited in 2009 after working for 30 yres. at a county hosp. I was getting to retire at the age of 47 with full benefits. I was goin to go back to college and do somthing with my life. Within six months fo my retiremnt I have had my 2nd cervicle fusion. ankle pain w/no injury and now heel surgery for a crumbled bone in heel which needed fused which was done 6/2011. I have been in the hosp. 7 times since retirement I feel this could be caused from the Nexium/Prilosec I have taken for10 yrs. Some retirement Huh? My foot surgeon says my bones are very soft and she is worried that my fusion may collapse and not hopd.

  3. Frances Reply

    I have been on Prilosec or its generic form since it first came on the market.
    I have been asking my doctrors to help me get off this drug because I felt it was not good to be on a drug for such a long period of time. I was constantly told that it was perfectly safe & I absolutely had to stay on it.I have recently suffered from psiatica due to damaged vertebrae & broke my ankle. I was on mg and have recently got myself down to 10 mg once a day. I also have a large hyatal hernia. My doctor finally admits there could be a problem with the omeprazole.

  4. Kim Reply

    I filed a claim but have not heard anything back. How do i find out about any potential settlement on my claim?

  5. Dennis Reply

    I was just referred to an ALS clinic in Boston due to severe neurological symptoms I’ve been having for almost a year. I’ve been taking Prilosec OTC for about 3 years. After a lot of research, obviously not wanting to accept that I have ALS, I realized that omeprazole can also prevent your body from absorbing B & magnesium…I quit taking prilosec about 7 days ago and I can already see a vast improvement in my symptoms…who knows what would have happened if I had not done this research as my doctors didn’t put 2 and 2 together…

  6. Lu Reply

    I had open heart in March 2011 almost one year now. I have had RA. For years bone damage and of course Nexium for many years now today they (the drug company sent me a letter (because.I was takig Nexium and had open heart) wanting permission to my medical records does anyone know, why?? Or are they fishing?

  7. Sarah Reply

    Wow since November, I have been having tremendous issues with headaches, slurred speech, numbness, leg cramps. After reading Dennis above these are all early ALS indicators. Thats enough for me to get off this drug. I had what they can’t classify either a stroke/complicated migrane in November. No one contacted me about this drug or vimova or omezerprole for a long time. I almost died due to b12 defficiency that I am just learning was probably caused by this drug.

  8. Esther Reply

    I have 2 small kids using PEG tube since 2007. They are 8 years old and 7 years old.

    It is a long story of their conditions. To make it short their development has been decreased to the point where they cannot swallow properly.

    I just found out about this web and information. I need more information about nexium side effect because:
    1. I don’t know what happen to my kids’ bones because they cannot walk or stand at the moment.

    2. 7 year old has been suffering from enormous amount of saliva that many times causing him throw up… and other things that right now I just cannot say it in English. Sorry…

    But, I will value any information and/or assistance that can support my argument to the gastro doctor. She is persistent that nexium is safe to be taking for long time.

    By the way, we live in Jakarta, Indonesia … thanks.

  9. Kierston Reply

    My femur broke coming down my stairs. Then I fell. The pain was so tremendous I passed out. I’d never broke a bone in my life. I have been blessed with health and strength my entire 46 years. This was extraordinary and all of a sudden.

  10. keith Reply

    I’ve been on Nexium for at least 10-12 year’s 40 mg once daily I have noticed in the past 4-5 year’s my heart burn is worst or acid reflux ‘now I have an infection in my stomach and they don’t know the cause I have to go the 18th for my 2nd MRI my vein’s in my leg’s are popping out all over I went to seen a vascular surgeon too find out if I had a bad blood circulation but he said the circulation was fine . my leg’s are weak and give out . could the Nexium be causing these kind’s of problem’s ?

  11. Carl Reply

    I was started on Prilosec back in about 2000. It caused a lot of abdominal cramping as though I could ‘feel’ my meals as it passed through me. So, my doctor switch me to Nexium which I took for the following 11 or so years, then to Omeprazole now for five years. I have been having back problems, they had found a fracture in my back, plus had open heart surgery. I just started to get myself off PPI’s to an OTC acid reducer. Think I have become deficient in B12. Been tested, no results yet.

  12. Wilma Reply

    I have been on Nexium for 8 years I now have pain in my kidneys and arthritis could this be the cause

  13. Sharrie Reply

    i have been on Nexium or Prilosec for the past 20 yrs.I have starting in 2013, open heart surgery, maze valve repair- 3 cardio conversions, a-fib,2 pace makers, in the hospital eight times in yr of 2013, have been in chronic pain for yrs. with cervical and lumbar stenosis, degeneration in several areas of spine and herination, two back surgeries. While in hosp for heart found Hiatal Hernia, and Colon Cancer.I now am told just one week ago today that I have Kidney damage with mild failure. I worked hard all my life and had basically pretty good health. i have referred to this Proton as my miracle pill . It helps me so much. I can swallow with it.. Just found out about the kidneys -What lies ahead for me?? I have been in pain every day for so long, and tried to build a tolerance to pain is not easy, but we must keep going . I had such pain in my knees for several yrs. that finally i had to have both of them replaced. I look at this article & it sounds like the words of a hypochondriac, but so untrue. To see this warning article after all this suffering has just blown me away. To think where could I be today? / Had I not gone through all these Health issues- Due to a drug destroying ones health along the way of it helping you in so many other ways. just going cold turkey , I can not swallow & was to the point that the Reflux got so bad I was having heartburn from everything that went in my mouth. Where do I turn from here? Make pre-arrangements with the Funeral home.

  14. William Reply

    I have been taking 40mg of Nexium for nine years due to Barrett’s Esophagus, otherwise I would probably have developed cancer by now. Nothing like being between a rock and a hard place.

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