Nexium, Prilosec and Other Acid Reflux Drug Lawsuits


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Side effects of Nexium, Prilosec and other blockbuster heartburn and acid reflux medications have been linked to a risk of acute kidney injury, chronic kidney disease and potentially kidney failure. However, it appears that inadequate warnings may have been provided to consumers and the medical community.

ACID REFLUX DRUG LAWSUIT STATUS:: Product liability lawyers are reviewing potential Nexium lawsuits, Prilosec lawsuits and other claims involving side effects of acid reflux drugs known as proton pump inhibitors (PPI). Potential claims are being reviewed for users who suffered any of the following injuries:

  • Acute Kidney Injury
  • Acute Interstitial Nephritis
  • Chronic Kidney Disease
  • Kidney or Renal Failure

As a result of the drug makers’ failure to warn about the link between acid reflux drugs and kidney problems, financial compensation may be available for users of any of the following proton pump inhibitors:

  • Nexium
  • Prilosec
  • Dexilant
  • Protonix
  • Prevacid
  • AcipHex
  • Vimovo
  • Zegarid


OVERVIEW: Proton pump inhibitors (PPI) are a popular class of medications used to reduce the amount of acid in the stomach, treating gastroesophageal reflux disease (GERD), heartburn, acid reflux, ulcers in the stomach and small intestines and inflammation of the esophagus.

The class of medications includes some of the most widely used drugs in the United States, with brand-name, generic and over-the-counter versions of Nexium, Prilosec and other drugs generating over $14 billion in annual sales.

The medications have been aggressively promoted as safe and effective, suggesting that users face little risk of side effects from Nexium, Prilosec or other acid reflux drugs. However, a number of studies have suggested that users may face a potential risk of kidney injury, kidney disease or kidney failure.

In December 2014, the FDA required new acid reflux drug warnings for Nexium, Prilosec and other proton pump inhibitors, indicating that some users have experienced acute interstitial nephritis, which involves an inflammation of hte kidneys that may lead to chronic and long-term injury. However, it appears that the manufacturers knew or should have known about the potential kidney risks with acid reflux drugs and failed to provide adequate warnings and information.

NEXIUM KIDNEY INJURY RISK: In April 2015, a study published in the medical journal CMAJ Open indicated that Nexium, Prilosec and other proton pump inhibitors are an under appreciated cause of acute kidney injury, finding that some users may be 2.5 times more likely to develop this condition that involves abrupt loss of kidney function.

Researchers warned about the link between acid reflux drugs and kidney injury, indicating that the condition may not be readily attributed to the treatment.

The study involved a review of data on 300,000 people aged 66 and older who started acid reflux treatment with a proton pump inhibitor from April 2002 to November 2011. Elderly users were found to be more likely to suffer acute kidney injury on Nexium, Prilosec or another PPI, when compared to users who were not taking the drug. Similarly, the risk of acute interstitial nephritis from the acid reflux drugs was tripled for those users.

Another study, published in February 2017, found that Nexium, Prilosec and other proton pump inhibitors were associated with an increased risk of kidney disease and kidney failure, even among individuals who do not experience an acute kidney injury (AKI) first.

CHRONIC KIDNEY DISEASE FROM PPI ACID REFLUX DRUGS: In January 2016, a study published in the medical journal JAMA Internal Medicine examined whether this popular class of drugs may also increase the risk of chronic kidney disease, which is a longer-term condition that may lead to kidney failure and the need for dialysis treatment or a kidney transplant.

Researchers reviewed data on 10,482 participants in the Atherosclerosis Risk in Communities study from February 1996 to December 2011, looking at self-reported heartburn drug use and outpatient prescriptions.

The study found that there was a 45% increased risk of chronic kidney disease with proton pump inhibitors (PPI).

NEXIUM BONE PROBLEMS: In May 2010, the FDA warned that there may be increased risk of bone fracture from prescription strength heartburn drugs like Nexium. The FDA required an update to the warning label about the risk of fractures from Nexium and other drugs in the class. FDA investigators determined that the risk of fractures is dose-specific and have not applied the Nexium bone fracture warning requirements to the over-the-counter versions of Nexium or similar PPIs.

Although multiple studies suggested that users may face an increased risk of bone problems from Nexium, AstraZeneca continued to market the medication without warning about the risk of bone deterioration, osteoporosis or fractures, according to allegations raised in several Nexium bone fracture lawsuits filed around that time.

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  1. James Reply

    I have been taking NEXIUM for about eight years. I have Rheumatoid Arthritis and Osteoarthritis. Could the NEXIUM have caused the aching in my right hip and legs?


  2. Denise Reply

    I have taken Nexium and Prilosec since 2001. I was so excited in 2009 after working for 30 yres. at a county hosp. I was getting to retire at the age of 47 with full benefits. I was goin to go back to college and do somthing with my life. Within six months fo my retiremnt I have had my 2nd cervicle fusion. ankle pain w/no injury and now heel surgery for a crumbled bone in heel which needed fused which was done 6/2011. I have been in the hosp. 7 times since retirement I feel this could be caused from the Nexium/Prilosec I have taken for10 yrs. Some retirement Huh? My foot surgeon says my bones are very soft and she is worried that my fusion may collapse and not hopd.

  3. Frances Reply

    I have been on Prilosec or its generic form since it first came on the market.
    I have been asking my doctrors to help me get off this drug because I felt it was not good to be on a drug for such a long period of time. I was constantly told that it was perfectly safe & I absolutely had to stay on it.I have recently suffered from psiatica due to damaged vertebrae & broke my ankle. I was on mg and have recently got myself down to 10 mg once a day. I also have a large hyatal hernia. My doctor finally admits there could be a problem with the omeprazole.

  4. Kim Reply

    I filed a claim but have not heard anything back. How do i find out about any potential settlement on my claim?

  5. Dennis Reply

    I was just referred to an ALS clinic in Boston due to severe neurological symptoms I’ve been having for almost a year. I’ve been taking Prilosec OTC for about 3 years. After a lot of research, obviously not wanting to accept that I have ALS, I realized that omeprazole can also prevent your body from absorbing B & magnesium…I quit taking prilosec about 7 days ago and I can already see a vast improvement in my symptoms…who knows what would have happened if I had not done this research as my doctors didn’t put 2 and 2 together…

  6. Lu Reply

    I had open heart in March 2011 almost one year now. I have had RA. For years bone damage and of course Nexium for many years now today they (the drug company sent me a letter (because.I was takig Nexium and had open heart) wanting permission to my medical records does anyone know, why?? Or are they fishing?

  7. Sarah Reply

    Wow since November, I have been having tremendous issues with headaches, slurred speech, numbness, leg cramps. After reading Dennis above these are all early ALS indicators. Thats enough for me to get off this drug. I had what they can’t classify either a stroke/complicated migrane in November. No one contacted me about this drug or vimova or omezerprole for a long time. I almost died due to b12 defficiency that I am just learning was probably caused by this drug.

  8. Esther Reply

    I have 2 small kids using PEG tube since 2007. They are 8 years old and 7 years old.

    It is a long story of their conditions. To make it short their development has been decreased to the point where they cannot swallow properly.

    I just found out about this web and information. I need more information about nexium side effect because:
    1. I don’t know what happen to my kids’ bones because they cannot walk or stand at the moment.

    2. 7 year old has been suffering from enormous amount of saliva that many times causing him throw up… and other things that right now I just cannot say it in English. Sorry…

    But, I will value any information and/or assistance that can support my argument to the gastro doctor. She is persistent that nexium is safe to be taking for long time.

    By the way, we live in Jakarta, Indonesia … thanks.

  9. Kierston Reply

    My femur broke coming down my stairs. Then I fell. The pain was so tremendous I passed out. I’d never broke a bone in my life. I have been blessed with health and strength my entire 46 years. This was extraordinary and all of a sudden.

  10. keith Reply

    I’ve been on Nexium for at least 10-12 year’s 40 mg once daily I have noticed in the past 4-5 year’s my heart burn is worst or acid reflux ‘now I have an infection in my stomach and they don’t know the cause I have to go the 18th for my 2nd MRI my vein’s in my leg’s are popping out all over I went to seen a vascular surgeon too find out if I had a bad blood circulation but he said the circulation was fine . my leg’s are weak and give out . could the Nexium be causing these kind’s of problem’s ?

  11. Carl Reply

    I was started on Prilosec back in about 2000. It caused a lot of abdominal cramping as though I could ‘feel’ my meals as it passed through me. So, my doctor switch me to Nexium which I took for the following 11 or so years, then to Omeprazole now for five years. I have been having back problems, they had found a fracture in my back, plus had open heart surgery. I just started to get myself off PPI’s to an OTC acid reducer. Think I have become deficient in B12. Been tested, no results yet.

  12. Wilma Reply

    I have been on Nexium for 8 years I now have pain in my kidneys and arthritis could this be the cause

  13. Sharrie Reply

    i have been on Nexium or Prilosec for the past 20 yrs.I have starting in 2013, open heart surgery, maze valve repair- 3 cardio conversions, a-fib,2 pace makers, in the hospital eight times in yr of 2013, have been in chronic pain for yrs. with cervical and lumbar stenosis, degeneration in several areas of spine and herination, two back surgeries. While in hosp for heart found Hiatal Hernia, and Colon Cancer.I now am told just one week ago today that I have Kidney damage with mild failure. I worked hard all my life and had basically pretty good health. i have referred to this Proton as my miracle pill . It helps me so much. I can swallow with it.. Just found out about the kidneys -What lies ahead for me?? I have been in pain every day for so long, and tried to build a tolerance to pain is not easy, but we must keep going . I had such pain in my knees for several yrs. that finally i had to have both of them replaced. I look at this article & it sounds like the words of a hypochondriac, but so untrue. To see this warning article after all this suffering has just blown me away. To think where could I be today? / Had I not gone through all these Health issues- Due to a drug destroying ones health along the way of it helping you in so many other ways. just going cold turkey , I can not swallow & was to the point that the Reflux got so bad I was having heartburn from everything that went in my mouth. Where do I turn from here? Make pre-arrangements with the Funeral home.

  14. William Reply

    I have been taking 40mg of Nexium for nine years due to Barrett’s Esophagus, otherwise I would probably have developed cancer by now. Nothing like being between a rock and a hard place.

  15. Doris Reply

    I was diagnosed in 2005 with H. Pylori and was prescribed 2 rounds of antibiotics along with Nexium. I have been on this drug since then because of acid reflux getting much worse if I miss a dose. Last year, I was diagnosed with severe diverticulitis, plus kidney infections and had to undergo a colon resection. I was one of the lucky ones and do not need a bag. I am 68 years old and have always enjoyed great health; but, I am so fuzzy headed-forgetful now, ache in joints, weak feeling constantly and generally feel lethargic. The Nexium should be tested for it’s effect on the digestive system (large and small intestines); the depletion of magnesium and calcium – plus other minerals and vitamins.

  16. JAMES Reply


  17. Pamela Reply

    I am 44 years old female. I was on prilosec then nexium for year’s, first started when I was 14 I was diagnosed with colon cancer, youngest person ever diagnosed in Huntsville Alabama. Then they put me on nexium I took it for years, I have been diagnosed with uterun cancer, breast cancer, and a cancerous mole off my back. I have suffered from my leg bone coming out of my hip bone for year’s and the doctors can’t explain it. I’ve now been diagnosed with osteoporosis, rheumatoid arthritis, osteoarthritis and something called crippling arthritis. I’m way too young to have been through all this just because of a prescription that I was lead to believe was safe. I’ve suffered more in the last 4 years. Plus I was in the hospital for 5 days with a abscess on my left kidney and ran a fever of 104 for 10 days. My feet, legs, hands, arms and back hurt all the time. My fingers feel like they are on fire.

  18. Sheri Reply

    I have been on meds for acid reflux for may years. Was on Previcid (sometimes up to 4x/day) for 10+ years. Currently take Nexium 40mg 2x/day. I am diligent about physical and lab work every year and try to live a healthy lifesytle. I am not aware of any short term effects, don’t know if there are long term effects. It’s scary to take meds for one condition only to find out further research determines there could be other side effects that were not known to the public or were later discovered. Makes ya wonder if the benefit outweighs the risk.

  19. rosalie Reply

    I have been on previcid for 12 years + and now I am in stage 4 chronic kidney dieases-not forsure what my next step will be possible dialysis?

  20. Deborah Reply

    I have been on Meds for acid reflux for more years than I can remember. I have memory problems, severe leg pain, 2 colon Test years apart that came back with pre-cancer polyps 2 removed on each test done, blood clot removed from bowels, kidneys always shows blood in urinalysis, pain in all joints, hernia, arthritis in neck, back, hands. Carpel Tunnel in hands. Feet burn and hurt so bad I have a hard time getting started in the AM hours. Could some of this be from taking this drug? I would like to be added to this claim. Thank you.

  21. jeanne Reply

    There is a remedy for acid reflux which doctors don’t always recommend (no financial kickback from the drug companies).
    That remedy is to raise the head of your bed, so that you sleep on a slight slope….Not flat. Gastric juice cannot flow up into your esophagus. One brick or block of wood will suffice. (Adding another pillow doesn’t help.)

  22. Jeanne Reply

    Forget meds! Raise the head of your bed. Gastric juice can’t flow uphill. Case closed.

  23. Vonda Reply

    I have had GERD since 1997. I have been on omeprozol, Nexium, Prilosec and Zantac. I am on another prescribed drug now I will have to get the name of it but it’s a generic for Nexium. I have had kidney issue, blood in urine, kidney infections, Piloafronitis I am sure I spelled that wrong. But two years ago I broke my ankle and I have a lot of the symptoms that most of you have such as back pain, muscle aches, burning and numbness in hands and feet, leg pain etc.. I would like to be included in this law suite.

  24. sandy Reply

    The first Dr. who put me on Nexium was a gastro specialist, however after about 6 years my family ph,ysician lowered the dose and stated that these types of drugs thin your bones. After falling and hurting my ankle, for no other reason as to it just gave out and it hurting chronically I’m beginning to believe it.

  25. Constance Reply

    Used many of these drugs for years for reflux and have many of these symptoms and take more drugs for the symptoms. Should I be in this suit?

  26. Jean Reply

    I’ve been on prescription pepcid for many years. It’s generic called Famotidine 40 mg I already sent info about medical issues these proton pump meds could be causing me- I.e.
    But I am very close to having to go on dialysis. My bun & creatinine ratio indicates massive damage in my kidneys. I get severe kidney pain, I was in hospital in December 2016 and I was & am magnesium deficient, along with many B vitamins and a # of minerals.
    I have other medical issues that fit into the problems I am just learning that these proton pump meds can cause.
    I believe I have a big case or more than 1 case. I don’t know how this works. But I get pneumonia 2-3 x a year, and am just about to loose kidney function. I have a lot of neurological probs
    Arthritis (both types) loosing my vision fast! And other medical issues that may have been caused by taking Famotidine 40 mg
    1 or 2 x daily.

  27. Randy Reply

    I have been on protonix for years now I am on dialasys I am tired of deign given drugs that cause worse things than they help and not being informed of all side effects

  28. brenda Reply

    I have been on these meds for many many years of my life…I have suffered from many problems with my stomach and my asphegus that let me to had to take them every day twice a day…I recently got my asphegus stretched and I got off of these meds now after all these years….!!! But I am noticing a lot of inflamation pain in my kidneys of late and have in the past. I also have arthritis in my back and have hip problems my docter had just diognosed me with , and severe knee problems and carpel tunnel , but unsure if they are a factor as well. I would like to be added to this claim. Thank you…

  29. kathy hutchinson Reply

    I took both Nexium, Prilosec and i lost my right kidney from a tumor. and my gallbladder in the same year. I stopped taken both when the nexium almost suffocated me . Now i am dealing with a tumor in my bladder ,,

  30. larry Reply

    in 2012 my doctor took me off ASIPHEX, NURPHROGIST BECAUSE OF THE INCREASE DAMAge it could cause me, with in the month I was starting dialisys. that was 4 years ago. now I have complications from dialisys

  31. Deborah Reply

    I too was taking Omeprazole for about 8 years or more. I was also diagnosed with chronic kidney disease about 4 years or so ago.
    I was diagnosed with lupus about 6 year ago. I have discord lupus which resulted in large red spots on my face, back,arms and chest. The itch was very intense!!!! Just taking a shower was so painful I would have tears rolling down my cheeks because of the clorine in the water it felt like I was on fire!!!! This past October I saw an article that stated that PPI’S could cause lupus or make it worse. I had seen my Doctor about a week before who said he had never seen me as bad. I was covered . He raise the dose of my medication but after reading the article about 4 days after seeing him I decided to stop the med. and also the Prilosec. Within 4 days I could see an improvement. Three weeks later I saw my Doctor again. He was in total shock!! His first words were{ [ [What happened,you are cleared up. what did you do} When I told him he agreed that it was the PPI. I contacted the company that makes it and was told that they did not have enough people reporting lupus so it was not listed as a side effect. They said that in July of 2016 it was listed. A LITTLE TOO LATE AS FAR AS I’M CONCERNED. That did not help with the pain and suffering for all those years from the lupus and kidney disease!!!! I AM SO VERY ANGRY!!!

  32. Richard Reply

    I also took omeprazole daily for 8 years or more until diagnosed with 2 cancers in early 2010.
    Papillary Renal Cell Carcinoma of the left kidney and Adenocarcinoma of the Gallbladder. Later to find in late 2011 that the Gallbladder cancer had somehow spread to the liver although the pathology report of the Gallbladder said there was a 5mm serosal margin before it would escape to liver.
    Forever grateful for my doctors who got me into the 5 year, 5% survivors of GB cancer.
    I just hit the 5 year cancer free after the liver ablation of 2012.
    I can assure you the PTSD of this ordeal hasn’t gone away like the removal of the left Kidney, Gallbladder, and ablated damaged liver!
    When you get down to one kidney and a damaged liver you have to pay close attention to the seemingly safe OTC meds you take for pain, some stress your kidney others your liver. I believe my life was changed because of my long term use of Omeprazole.
    My concerns seem a LOT like Kathy H above on 2/23/17. Will cancer be considered as part of this suite?

  33. Mildred Reply

    I now have kidney problems and I have listed them below.

  34. Mark Reply

    I’ve been taking omepresole for 15 years and have a host of medical problems that could be related to taking this drug….I am also a type 1 diabetic which masked some of the symptoms….have had stents ,foot pain,joint pain, back pain….

  35. Janis Reply

    Carl, you do realize that Prilosec and Omeprazole are the same thing, right? Well, they are. Omeprazole is the generic version.

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