Nitrous Oxide Lawsuit Individuals who suffered harm, or families who lost a loved one after using nitrous oxide products may be eligible for financial compensation through a nitrous oxide lawsuit.
Depo-Provera Lawsuit Depo-Provera lawsuits are being investigated for women who developed meningioma brain tumors after receiving Depo-Provera birth control shots, claiming that Pfizer failed to adequately disclose side effects.
Hair Relaxer Lawsuit Regular exposure to chemicals in hair relaxer may cause uterine cancer, ovarian cancer and other injuries. Women diagnosed with cancer may be eligible for settlement benefits.
Sports Betting Addiction Lawsuit Sports betting addiction lawsuits are being investigated for college students and young adults who developed gambling problems after using apps like FanDuel and DraftKings, alleging that the platforms failed to warn about the addictive nature of their features and marketing practices.
Roblox Lawsuit Families are filing Roblox lawsuits after children were targeted by predators for grooming, sextortion, sexual abuse, or exploitation on the platform. Learn who qualifies, what cases allege, and how to file a confidential claim.
Dupixent Lawsuit Dupixent lawsuits are being investigated for patients who developed rare blood cancers such as cutaneous T-cell lymphoma (CTCL) after receiving injections, alleging that Sanofi and Regeneron failed to warn about the potential risks of immune suppression and delayed cancer diagnosis.
Tabletop Fire Pit Lawsuit Individuals who suffered severe burns, or families who lost a loved one in a tabletop fire pit explosion, may be eligible for financial compensation through a fire pit injury lawsuit.
Ozempic Lawsuit Lawyers are pursuing Ozempic lawsuits, Wegovy lawsuits and Mounjaro lawsuits over gastroparesis or stomach paralysis, which can leave users with long-term gastrointestinal side effects
Suboxone Tooth Decay Lawsuit Lawsuits are being pursued by users of Suboxone who experienced tooth loss, broken teeth or required dental extractions. Settlement benefits may be available.
Change Healthcare Lawsuit Lawyers are reviewing Change Healthcare class action lawsuits for individuals who had their personal information stolen due to the data breach.
FDA Announces New Recommendations for Acceptable Limits of Nitrosamine in Drugs Guidance comes after a number of massive drug recalls issued in recent years due to nitrosamine contamination, which could increase cancer risks. August 9, 2023 Irvin Jackson Add Your Comments Federal drug regulators have issued a new draft guidance that sets the acceptable limits for dozens of toxic chemicals known as nitrosamines, which can contaminate medications as a byproduct of the manufacturing process and expose users to an increased risk of cancer. The U.S. Food and Drug Administration (FDA) issued the recommendations for the industry on August 4, in a final guidance titled “Recommended Acceptable Intake Limits for Nitrosamine Drug Substance-Related Impurities (NDSRIs)”, which provides a framework for predicting the possible presence and likelihood of nitrosamine contamination, and for determining the levels of nitrosamine the FDA will accept. Concerns about nitrosamine drug contamination gained widespread attention in 2018, when a series of generic valsartan recalls were issued, after certain versions of the hypertension drug were found to contain unsafe levels of the chemical byproduct nitrosodimethylamine (NDMA), which is a potent human carcinogen. Following the recalls, regulators and drug manufacturers became more aware of nitrosames in drug products and the potential cancer risks, resulting in recalls for a number of different medications in recent years, including Chantix, Metformin and Zantac. This has led to numerous recalls and litigation, including more than 100,000 Zantac cancer lawsuits being filed against manufacturers of the heartburn drug. Stay Up-to-Date About Zantac Lawsuits AboutLawsuits.com sends a weekly digest email with information about recalls, lawsuits, and safety warnings that may impact your family, including any new Zantac lawsuit updates or legal developments. "*" indicates required fields Email* SIGN ME UP Δ Learn More Stay Up-to-Date About Zantac Lawsuits AboutLawsuits.com sends a weekly digest email with information about recalls, lawsuits, and safety warnings that may impact your family, including any new Zantac lawsuit updates or legal developments. "*" indicates required fields Email* SIGN ME UP Δ Learn More Widespread Nitrosamine Contamination Discovered In response to the growing problem, the FDA issued guidance in 2020 on how to detect and prevent nitrosamine impurities, which set daily acceptable limits for six different nitrosamines, including NDMA. The guidance was passed on the belief that the problem would be small, but the FDA underestimated the scope of the nitrosamine contamination issues. Hundreds of drugs turned out to have nitrosamines, many of them not on the list impacted by the FDA guidance. Regulators are now discovering that any drug with an active ingredient that includes a vulnerable amine, a type of nitrogen molecule usually derived from ammonia, could become contaminated with nitrosamine during the manufacturing process. That includes drugs such as angiotensin-converting enzyme (ACE) inhibitors used in hypertension drugs; beta blockers in many heart drugs, and selective serotonin reuptake inhibitors (SSRIs), which are commonly used antidepressants. Under the weight of the recalls, the 2020 guidance quickly became outdated, and the FDA had to decide what to do about all the other nitrosamines they keep discovering in commonly used drugs. New Acceptable Intake Guidance for Nitrosamine Contamination The new guidance recommends acceptable intake (AI) limits for certain nitrosamines across a wide array of drugs. However, it also recommends testing methods for certain nitrosamines, and how to calculate those levels in a way that is in accordance with FDA procedures. The agency notes that it will work with manufacturers to try to keep certain key drugs on the market, particularly if issuing a recall would lead to a shortage. This may include interim acceptable limits which are more lenient than usual. “When contacted about a potential disruption in the drug supply, FDA intends to evaluate each circumstance on a case-by-case basis,” the guidance states. “FDA may work directly with a specific manufacturer or applicant of the marketed drug and intends to consider whether it is appropriate or not appropriate to recommend an interim AI limit for a temporary period.” The AI limits vary with the drug type and the nitrosamine byproduct related to it. For example, the FDA set a recommended AI limit for N-nitroso-varenicline, found in the smoking cessation drug Chantix, to a maximum of 37 nanograms per day. However, the antidepressant Cymbalta can expose users to up to 100 ng/day of N-nitroso-duloxetine. Written by: Irvin Jackson Senior Legal Journalist & Contributing Editor Irvin Jackson is a senior investigative reporter at AboutLawsuits.com with more than 30 years of experience covering mass tort litigation, environmental policy, and consumer safety. He previously served as Associate Editor at Inside the EPA and contributes original reporting on product liability lawsuits, regulatory failures, and nationwide litigation trends. Tags: Cancer, Chantix, Chemicals, NDMA, Nitrosamines, Valsartan, Zantac More Zantac Lawsuit Stories Zantac Cancer Lawsuits Continue To Be Filed More Than 5 Years After Recall June 18, 2025 Jury Hears Zantac Cancer Evidence in Illinois Trial Against Boehringer Ingelheim February 5, 2025 Zantac Bladder Cancer Lawsuit Trial Ends With Hung Jury in California November 22, 2024 0 Comments Share Your CommentsFirst Name*Last NameEmail* Shared Comments*This field is hidden when viewing the formI authorize the above comments be posted on this page Yes No Post Comment I authorize the above comments be posted on this page Weekly Digest Opt-In Yes, send me a weekly email with the latest lawsuits, recalls and warnings. Want your comments reviewed by a lawyer?To have an attorney review your comments and contact you about a potential case, provide your contact information below. This will not be published.Contact Phone #Alt Phone #Private CommentsNOTE: Providing information for review by an attorney does not form an attorney-client relationship.CAPTCHAGA SourceGA CampaignGA MediumGA ContentGA TermCommentsThis field is for validation purposes and should be left unchanged. Δ MORE TOP STORIES Safety Problems With Roblox and Discord Endangered Young Girl: Lawsuit (Posted: today) A Texas mother is pursuing a lawsuit against Roblox and Discord, claiming the design of the apps allow sexual predators to access and groom young children. 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Safety Problems With Roblox and Discord Endangered Young Girl: Lawsuit (Posted: today) A Texas mother is pursuing a lawsuit against Roblox and Discord, claiming the design of the apps allow sexual predators to access and groom young children. MORE ABOUT: ROBLOX LAWSUITLawsuit Alleges Roblox Lacks Safeguards To Protect Children From Sexual Predators (09/11/2025)Roblox Age Verification Technology To Be Implemented Amid Child Exploitation Lawsuits (09/09/2025)Roblox Kidnapping Lawsuit Filed After Child Was Abducted and Sexually Trafficked (09/03/2025)
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