Andexxa Blood Clot Risks Lead to FDA Questions Regarding Safety of the Reversal Agent for Xarelto, Eliquis
Xarelto Side Effects More Likely to Result in Death than Warfarin for Afib Patients with Heart Disease: Study
Side Effects of Blood Thinners, Diabetes Drugs Are Leading Causes of ER Visits Due to Medications: Study
Sports Betting Addiction Lawsuit Sports betting addiction lawsuits are being investigated for college students and young adults who developed gambling problems after using apps like FanDuel and DraftKings, alleging that the platforms failed to warn about the addictive nature of their features and marketing practices.
Nitrous Oxide Lawsuit Individuals who suffered harm, or families who lost a loved one after using nitrous oxide products may be eligible for financial compensation through a nitrous oxide lawsuit.
Hair Relaxer Lawsuit Regular exposure to chemicals in hair relaxer may cause uterine cancer, ovarian cancer and other injuries. Women diagnosed with cancer may be eligible for settlement benefits.
Depo-Provera Lawsuit Depo-Provera lawsuits are being investigated for women who developed meningioma brain tumors after receiving Depo-Provera birth control shots, claiming that Pfizer failed to adequately disclose side effects.
Ozempic Lawsuit Lawyers are pursuing Ozempic lawsuits, Wegovy lawsuits and Mounjaro lawsuits over gastroparesis or stomach paralysis, which can leave users with long-term gastrointestinal side effects
Suboxone Tooth Decay Lawsuit Lawsuits are being pursued by users of Suboxone who experienced tooth loss, broken teeth or required dental extractions. Settlement benefits may be available.
Change Healthcare Lawsuit Lawyers are reviewing Change Healthcare class action lawsuits for individuals who had their personal information stolen due to the data breach.
Bard PowerPort Lawsuit Serious and life-threatening injuries have been linked to problems with Bard PowerPort. Lawsuits are now being pursued by individuals who suffered injuries from the implantable port catheter fracturing or migrating.
AngioDynamics Port Catheter Lawsuit Serious and life-threatening injuries have been linked to problems with Bard PowerPort. Lawsuits are now being pursued by individuals who suffered injuries from the implantable port catheter fracturing or migrating.
Processed Food Lawsuit Lawsuits are being pursued against the food industry over their manufacturing and advertising of ultra-processed foods, which have caused a generation of children to face an increased risk of developing childhood diabetes and other chronic illnesses.
Reversal Agent for Uncontrollable Xarelto Bleeding Delayed by FDA August 22, 2016 Irvin Jackson Add Your Comments Although problems with uncontrollable bleeding on Xarelto and Eliquis have caused thousands of severe injuries and deaths, Federal regulators have rejected a proposed antidote for the new-generation anticoagulants, requesting additional information before approving the reversal agent as safe and effective. Portola Pharmaceuticals issued a press release last week, announcing that it has received a Complete Response Letter (CRL) from the FDA, delaying the approval of AndexXa, which has been proposed as a reversal agent for a new class of anticoagulants, known as Factor Xa inhibitors. The drug is designed to reverse the blood thinning effects of the anticoagulants, allowing doctors to control and stop bleeding events that may occur among users of Xarelto, Eliquis and other similar blood thinners. Learn More About Xarelto Lawsuits Side Effects of Xarelto May Increase Risk of Uncontrollable Bleeding. Learn More SEE IF YOU QUALIFY FOR COMPENSATION Learn More About Xarelto Lawsuits Side Effects of Xarelto May Increase Risk of Uncontrollable Bleeding. Learn More SEE IF YOU QUALIFY FOR COMPENSATION While warfarin has been the go-to anticoagulant treatment for decades, Xarelto, Eliquis and other new-generation anticoagulants have been introduced in recent years as a superior alternative, indicating that they are easier to use and require less blood monitoring to maintain the proper dose. However, unlike warfarin, where the blood thinning effects of the drug can be reversed quickly with vitamin K and fresh frozen plasma if bleeding problems develop, no safe and effective antidote has been approved for use with Xarelto and Eliquis. Since the drugs have hit the market, thousands of reports involving uncontrollable Xarelto bleeding problems have plagued the new drugs, and there are currently more than 7,000 Xarelto injury lawsuits pending nationwide, alleging that the Bayer Healthcare and Janssen Pharmaceuticals sold an unreasonably dangerous and defective anticoagulant, without warning about the lack of an available reversal agent. AndexXa (andexanet alfa) was developed by Portola, and approval was expected last week. However, the FDA indicates that it requires additional information regarding the manufacturing of the drug, and data on whether the drug can be used with the blood thinners Savaysa and Lovenox, according to the Portola press release. The FDA did approve Praxbind in October 2015, which is a reversal agent for the Factor Xa inhibitor Pradaxa, which was the first member of this class to hit the market. However, Portola sought approval to market AndexXa as a reversal agent for Xarelto and Eliquis, which were the second and third members of this class, respectively. The approval of a reversal agent for Xarelto and Eliquis has been sought by the drug makers, since it is widely acknowledged that this will make the drugs substantially safer. While Portola indicates that it is working with the FDA and remains confident in its ability to get AndexXa approved, CEO Bill Lis reportedly said in a conference call on Thursday that the FDA letter was “disappointing.” According to allegations raised in product liability lawsuits filed against the drug makers, they never should have introduced the new generation anticoagulants before a safe and effective reversal agent was introduced, seeking damages for severe bleeds and wrongful deaths caused by bleeding problems on Xarelto and Eliquis. A series of Xarelto bellwether trials are expected to begin early next year in the federal court system, which are designed to help parties gauge how juries may respond to certain evidence and testimony that is likely to be repeated throughout the litigation. Thousands of Pradaxa lawsuits were filed against the makers of that competitor drug before the introduction of Praxbind, and the drug makers ultimately agreed to pay $650 million to settle about 4,000 cases. It is widely expected that Xarelto settlements will require a substantially larger payment, given the larger market share and wider spread reports of problems among users of the controversial anticoagulant. Tags: Bleeding, Blood Thinners, Eliquis, Lovenox, Portola Pharmaceuticals, Pradaxa, Savaysa, Warfarin, Xarelto More Xarelto Lawsuit Stories Andexxa Blood Clot Risks Lead to FDA Questions Regarding Safety of the Reversal Agent for Xarelto, Eliquis November 21, 2024 Xarelto Side Effects More Likely to Result in Death than Warfarin for Afib Patients with Heart Disease: Study September 1, 2022 Side Effects of Blood Thinners, Diabetes Drugs Are Leading Causes of ER Visits Due to Medications: Study October 15, 2021 0 Comments Share Your CommentsFirst Name*Last NameEmail* Shared Comments*This field is hidden when viewing the formI authorize the above comments be posted on this page Yes No Post Comment I authorize the above comments be posted on this page Weekly Digest Opt-In Yes, send me a weekly email with the latest lawsuits, recalls and warnings. 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